Redesign of carnitine acetyltransferase specificity by protein engineering

Medicine & Life Sciences

• Acetyl Coenzyme A 16%
• Acetylcarnitine 18%
• Amino Acids 4%
• Carnitine 7%
• Carnitine O-Acetyltransferase 100%
• carnitine octanoyltransferase 38%
• Catalytic Domain 5%
• Coenzyme A 16%
• Energy Metabolism 5%
• Eukaryota 6%
• Fatty Acids 5%
• Glycine 6%
• Kinetics 4%
• Methionine 6%
• Mutation 3%
• Protein Engineering 79%
• Substrate Specificity 7%

Chemistry

• Acetyl-CoA 11%
• Acid 1%
• Block Like Crystal 3%
• Carnitine 78%
• Energy 2%
• Fatty Acid 3%
• Glycine 3%
• Methionine 4%
• Modification 2%
• Mutation 3%
• Pharmacological Metabolism 3%
• Protein 23%