TY - JOUR
T1 - Redox proteomics identification of oxidatively modified brain proteins in inherited Alzheimer's disease
T2 - An initial assessment
AU - Butterfield, D. Allan
AU - Gnjec, Anastazija
AU - Poon, H. Fai
AU - Castegna, Alessandra
AU - Pierce, William M.
AU - Klein, Jon B.
AU - Martins, Ralph N.
PY - 2006
Y1 - 2006
N2 - Objective: To identify oxidatively modified proteins in brains of persons with inherited Alzheimer's disease. Methods: Redox proteomics was used to identify oxidatively modified brain proteins in persons with mutations in the genes for presenilin-1 (PS-1). Results: An initial redox proteomics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), γ-enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. Conclusions: These initial results suggest that oxidatively modified proteins are important common features in both familial and sporadic AD.
AB - Objective: To identify oxidatively modified proteins in brains of persons with inherited Alzheimer's disease. Methods: Redox proteomics was used to identify oxidatively modified brain proteins in persons with mutations in the genes for presenilin-1 (PS-1). Results: An initial redox proteomics assessment of oxidatively modified proteins from brains of individuals with PS-1 mutations was performed. These PS1 mutations, Q222H and M233T, are completely penetrant causing early-onset familial AD as previously reported in these Australian families. We show that oxidative modifications of ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), γ-enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH-1) are present in the brain of familial AD subjects. Conclusions: These initial results suggest that oxidatively modified proteins are important common features in both familial and sporadic AD.
KW - Familial Alzheimer's disease
KW - Oxidatively modified brain proteins
KW - Redox proteomics
UR - http://www.scopus.com/inward/record.url?scp=33847069643&partnerID=8YFLogxK
M3 - Article
C2 - 17183150
AN - SCOPUS:33847069643
SN - 1387-2877
VL - 10
SP - 391
EP - 397
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -