Reduced T helper and B lymphocytes in Parkinson's disease

Claire H. Stevens; Dominic Rowe; Marie Christine Morel-Kopp; Carolyn Orr; Tonia Russell; Madelaine Ranola; Christopher Ward; Glenda M. Halliday

doi:10.1016/j.jneuroim.2012.07.015

Reduced T helper and B lymphocytes in Parkinson's disease

Claire H. Stevens, Dominic Rowe, Marie Christine Morel-Kopp, Carolyn Orr, Tonia Russell, Madelaine Ranola, Christopher Ward, Glenda M. Halliday^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

161 Citations (Scopus)

Abstract

Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4. + T and CD19. + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.

Original language	English
Pages (from-to)	95-99
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	252
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.07.015
Publication status	Published - 14 Nov 2012

Keywords

Parkinson's disease
T lymphocytes
B lymphocytes

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10.1016/j.jneuroim.2012.07.015

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title = "Reduced T helper and B lymphocytes in Parkinson's disease",

abstract = "Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4. + T and CD19. + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.",

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AU - Stevens, Claire H.

AU - Rowe, Dominic

AU - Morel-Kopp, Marie Christine

AU - Orr, Carolyn

AU - Russell, Tonia

AU - Ranola, Madelaine

AU - Ward, Christopher

AU - Halliday, Glenda M.

PY - 2012/11/14

Y1 - 2012/11/14

N2 - Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4. + T and CD19. + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.

AB - Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4. + T and CD19. + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.

KW - Parkinson's disease

KW - T lymphocytes

KW - B lymphocytes

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Reduced T helper and B lymphocytes in Parkinson's disease

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Keywords

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