Reduced T helper and B lymphocytes in Parkinson's disease

Claire H. Stevens, Dominic Rowe, Marie Christine Morel-Kopp, Carolyn Orr, Tonia Russell, Madelaine Ranola, Christopher Ward, Glenda M. Halliday*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    73 Citations (Scopus)

    Abstract

    Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4. + T and CD19. + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.

    Original languageEnglish
    Pages (from-to)95-99
    Number of pages5
    JournalJournal of Neuroimmunology
    Volume252
    Issue number1-2
    DOIs
    Publication statusPublished - 14 Nov 2012

    Keywords

    • Parkinson's disease
    • T lymphocytes
    • B lymphocytes

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    Stevens, C. H., Rowe, D., Morel-Kopp, M. C., Orr, C., Russell, T., Ranola, M., ... Halliday, G. M. (2012). Reduced T helper and B lymphocytes in Parkinson's disease. Journal of Neuroimmunology, 252(1-2), 95-99. https://doi.org/10.1016/j.jneuroim.2012.07.015