Refractive index tomography of turbid media by bifocal optical coherence refractometry

Andrei V. Zvyagin; Sergey A. Alexandrov; K. K M B Dilusha Silva; Timothy R. Hillman; Julian J. Armstrong; Takuya Tsuzuki; David D. Sampson

doi:10.1117/12.531272

Refractive index tomography of turbid media by bifocal optical coherence refractometry

Andrei V. Zvyagin^*, Sergey A. Alexandrov, K. K M B Dilusha Silva, Timothy R. Hillman, Julian J. Armstrong, Takuya Tsuzuki, David D. Sampson

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

1 Citation (Scopus)

Abstract

We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on the measurement of the optical pathlength difference between two foci simultaneously present in a medium of interest. We describe a new method to axially shift the bifocal optical pathlength that avoids the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, including video clips, which demonstrate refractive index tomography of a range of turbid liquid phantoms, as well as of human skin in vivo.

Original language	English
Title of host publication	Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
Place of Publication	Bellingham, Washington
Publisher	SPIE
Pages	155-166
Number of pages	12
Volume	5316
ISBN (Print)	0819452246
DOIs	https://doi.org/10.1117/12.531272
Publication status	Published - 2004
Externally published	Yes

Publication series

Name	Proceedings of SPIE
Publisher	SPIE
Volume	5316
ISSN (Print)	0277-786X

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10.1117/12.531272

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Zvyagin, A. V., Alexandrov, S. A., Dilusha Silva, K. K. M. B., Hillman, T. R., Armstrong, J. J., Tsuzuki, T., & Sampson, D. D. (2004). Refractive index tomography of turbid media by bifocal optical coherence refractometry. In Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII (Vol. 5316, pp. 155-166). (Proceedings of SPIE; Vol. 5316). SPIE. https://doi.org/10.1117/12.531272

@inproceedings{a11edcf2097d4b378f6f1e73873e7105,

title = "Refractive index tomography of turbid media by bifocal optical coherence refractometry",

abstract = "We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on the measurement of the optical pathlength difference between two foci simultaneously present in a medium of interest. We describe a new method to axially shift the bifocal optical pathlength that avoids the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, including video clips, which demonstrate refractive index tomography of a range of turbid liquid phantoms, as well as of human skin in vivo.",

author = "Zvyagin, {Andrei V.} and Alexandrov, {Sergey A.} and {Dilusha Silva}, {K. K M B} and Hillman, {Timothy R.} and Armstrong, {Julian J.} and Takuya Tsuzuki and Sampson, {David D.}",

year = "2004",

doi = "10.1117/12.531272",

language = "English",

isbn = "0819452246",

volume = "5316",

series = "Proceedings of SPIE",

publisher = "SPIE",

pages = "155--166",

booktitle = "Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII",

address = "United States",

}

Zvyagin, AV, Alexandrov, SA, Dilusha Silva, KKMB, Hillman, TR, Armstrong, JJ, Tsuzuki, T & Sampson, DD 2004, Refractive index tomography of turbid media by bifocal optical coherence refractometry. in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII. vol. 5316, Proceedings of SPIE, vol. 5316, SPIE, Bellingham, Washington, pp. 155-166. https://doi.org/10.1117/12.531272

Refractive index tomography of turbid media by bifocal optical coherence refractometry. / Zvyagin, Andrei V.; Alexandrov, Sergey A.; Dilusha Silva, K. K M B et al.
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII. Vol. 5316 Bellingham, Washington: SPIE, 2004. p. 155-166 (Proceedings of SPIE; Vol. 5316).

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

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T1 - Refractive index tomography of turbid media by bifocal optical coherence refractometry

AU - Zvyagin, Andrei V.

AU - Alexandrov, Sergey A.

AU - Dilusha Silva, K. K M B

AU - Hillman, Timothy R.

AU - Armstrong, Julian J.

AU - Tsuzuki, Takuya

AU - Sampson, David D.

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Y1 - 2004

N2 - We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on the measurement of the optical pathlength difference between two foci simultaneously present in a medium of interest. We describe a new method to axially shift the bifocal optical pathlength that avoids the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, including video clips, which demonstrate refractive index tomography of a range of turbid liquid phantoms, as well as of human skin in vivo.

AB - We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on the measurement of the optical pathlength difference between two foci simultaneously present in a medium of interest. We describe a new method to axially shift the bifocal optical pathlength that avoids the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, including video clips, which demonstrate refractive index tomography of a range of turbid liquid phantoms, as well as of human skin in vivo.

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DO - 10.1117/12.531272

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AN - SCOPUS:5644259801

SN - 0819452246

VL - 5316

T3 - Proceedings of SPIE

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EP - 166

BT - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII

PB - SPIE

CY - Bellingham, Washington

ER -

Zvyagin AV, Alexandrov SA, Dilusha Silva KKMB, Hillman TR, Armstrong JJ, Tsuzuki T et al. Refractive index tomography of turbid media by bifocal optical coherence refractometry. In Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII. Vol. 5316. Bellingham, Washington: SPIE. 2004. p. 155-166. (Proceedings of SPIE). doi: 10.1117/12.531272

Refractive index tomography of turbid media by bifocal optical coherence refractometry

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