Regional chromosomal assignment of human renin gene to lql2--->qter and use in linkage studies in Charcot-Marie-Tooth disease

L. R. Griffiths*, G. A. Nicholson, D. A. Ross, M. B. Zwi, J. G. McLeod, T. Mohandas, B. J. Morris

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The gene for renin, previously mapped to human chromosome 1, was further localized to lql2-”qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (A.HR5) could detect a/ftndlll restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalCytogenetic and Genome Research
Volume45
Issue number3-4
DOIs
Publication statusPublished - 1987
Externally publishedYes

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