Regional chromosomal assignment of human renin gene to lql2--->qter and use in linkage studies in Charcot-Marie-Tooth disease

L. R. Griffiths; G. A. Nicholson; D. A. Ross; M. B. Zwi; J. G. McLeod; T. Mohandas; B. J. Morris

doi:10.1159/000132459

Regional chromosomal assignment of human renin gene to lql2--->qter and use in linkage studies in Charcot-Marie-Tooth disease

L. R. Griffiths^*, G. A. Nicholson, D. A. Ross, M. B. Zwi, J. G. McLeod, T. Mohandas, B. J. Morris

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The gene for renin, previously mapped to human chromosome 1, was further localized to lql2-”qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (A.HR5) could detect a/ftndlll restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.

Original language	English
Pages (from-to)	231-233
Number of pages	3
Journal	Cytogenetic and Genome Research
Volume	45
Issue number	3-4
DOIs	https://doi.org/10.1159/000132459
Publication status	Published - 1987
Externally published	Yes

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title = "Regional chromosomal assignment of human renin gene to lql2--->qter and use in linkage studies in Charcot-Marie-Tooth disease",

abstract = "The gene for renin, previously mapped to human chromosome 1, was further localized to lql2-”qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (A.HR5) could detect a/ftndlll restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.",

author = "Griffiths, {L. R.} and Nicholson, {G. A.} and Ross, {D. A.} and Zwi, {M. B.} and McLeod, {J. G.} and T. Mohandas and Morris, {B. J.}",

year = "1987",

doi = "10.1159/000132459",

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volume = "45",

pages = "231--233",

journal = "Cytogenetic and Genome Research",

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TY - JOUR

T1 - Regional chromosomal assignment of human renin gene to lql2--->qter and use in linkage studies in Charcot-Marie-Tooth disease

AU - Griffiths, L. R.

AU - Nicholson, G. A.

AU - Ross, D. A.

AU - Zwi, M. B.

AU - McLeod, J. G.

AU - Mohandas, T.

AU - Morris, B. J.

PY - 1987

Y1 - 1987

N2 - The gene for renin, previously mapped to human chromosome 1, was further localized to lql2-”qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (A.HR5) could detect a/ftndlll restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.

AB - The gene for renin, previously mapped to human chromosome 1, was further localized to lql2-”qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (A.HR5) could detect a/ftndlll restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.

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U2 - 10.1159/000132459

DO - 10.1159/000132459

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C2 - 3319438

AN - SCOPUS:0023551105

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EP - 233

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

IS - 3-4

ER -

Regional chromosomal assignment of human renin gene to lql2--->qter and use in linkage studies in Charcot-Marie-Tooth disease

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