Regional differentiation of cortical activity in schizophrenia: a complementary approach to conventional analysis of regional cerebral blood flow

Stephen Hook; Evian Gordon; Ilario Lazzaro; Christine Burke; John Anderson; Yvonne Zurynski; Jeff Snars; Russell Meares

doi:10.1016/0925-4927(95)02421-S

Regional differentiation of cortical activity in schizophrenia: a complementary approach to conventional analysis of regional cerebral blood flow

Stephen Hook^*, Evian Gordon, Ilario Lazzaro, Christine Burke, John Anderson, Yvonne Zurynski, Jeff Snars, Russell Meares

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

This study examines an alternative to a narrow locus-of-dysfunction cortical pathophysiology in schizophrenia, which in turn suggests a modified approach to the analysis of data from regional cerebral blood flow studies. The results provide qualified support for a model of impaired differentiation of cortical activity in schizophrenia. As an index of the differentiation of cortical fields, regional gradients of cortical blood flow were examined. Medicated patients (n = 15) failed to show the differentiation of networks in frontal areas during a verbal memory recognition task observed in normal comparison subjects (n = 15). Unmedicated patients (n = 15) at rest tended to lose normal lateralization and had increased gradients in the right frontal area compared with normal comparison subjects.

Original language	English
Pages (from-to)	85-93
Number of pages	9
Journal	Psychiatry Research: Neuroimaging
Volume	61
Issue number	2
DOIs	https://doi.org/10.1016/0925-4927(95)02421-S
Publication status	Published - 8 Aug 1995
Externally published	Yes

Keywords

Cortex
Differentiation
Pathophysiology
RCBF
Schizophrenia

Access to Document

10.1016/0925-4927(95)02421-S

Cite this

@article{c3a9527ae1ba4c09ba9761219670650b,

title = "Regional differentiation of cortical activity in schizophrenia: a complementary approach to conventional analysis of regional cerebral blood flow",

abstract = "This study examines an alternative to a narrow locus-of-dysfunction cortical pathophysiology in schizophrenia, which in turn suggests a modified approach to the analysis of data from regional cerebral blood flow studies. The results provide qualified support for a model of impaired differentiation of cortical activity in schizophrenia. As an index of the differentiation of cortical fields, regional gradients of cortical blood flow were examined. Medicated patients (n = 15) failed to show the differentiation of networks in frontal areas during a verbal memory recognition task observed in normal comparison subjects (n = 15). Unmedicated patients (n = 15) at rest tended to lose normal lateralization and had increased gradients in the right frontal area compared with normal comparison subjects.",

keywords = "Cortex, Differentiation, Pathophysiology, RCBF, Schizophrenia",

author = "Stephen Hook and Evian Gordon and Ilario Lazzaro and Christine Burke and John Anderson and Yvonne Zurynski and Jeff Snars and Russell Meares",

year = "1995",

month = aug,

day = "8",

doi = "10.1016/0925-4927(95)02421-S",

language = "English",

volume = "61",

pages = "85--93",

journal = "Psychiatry Research: Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Regional differentiation of cortical activity in schizophrenia

T2 - a complementary approach to conventional analysis of regional cerebral blood flow

AU - Hook, Stephen

AU - Gordon, Evian

AU - Lazzaro, Ilario

AU - Burke, Christine

AU - Anderson, John

AU - Zurynski, Yvonne

AU - Snars, Jeff

AU - Meares, Russell

PY - 1995/8/8

Y1 - 1995/8/8

N2 - This study examines an alternative to a narrow locus-of-dysfunction cortical pathophysiology in schizophrenia, which in turn suggests a modified approach to the analysis of data from regional cerebral blood flow studies. The results provide qualified support for a model of impaired differentiation of cortical activity in schizophrenia. As an index of the differentiation of cortical fields, regional gradients of cortical blood flow were examined. Medicated patients (n = 15) failed to show the differentiation of networks in frontal areas during a verbal memory recognition task observed in normal comparison subjects (n = 15). Unmedicated patients (n = 15) at rest tended to lose normal lateralization and had increased gradients in the right frontal area compared with normal comparison subjects.

AB - This study examines an alternative to a narrow locus-of-dysfunction cortical pathophysiology in schizophrenia, which in turn suggests a modified approach to the analysis of data from regional cerebral blood flow studies. The results provide qualified support for a model of impaired differentiation of cortical activity in schizophrenia. As an index of the differentiation of cortical fields, regional gradients of cortical blood flow were examined. Medicated patients (n = 15) failed to show the differentiation of networks in frontal areas during a verbal memory recognition task observed in normal comparison subjects (n = 15). Unmedicated patients (n = 15) at rest tended to lose normal lateralization and had increased gradients in the right frontal area compared with normal comparison subjects.

KW - Cortex

KW - Differentiation

KW - Pathophysiology

KW - RCBF

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0029098894&partnerID=8YFLogxK

U2 - 10.1016/0925-4927(95)02421-S

DO - 10.1016/0925-4927(95)02421-S

M3 - Article

C2 - 7480391

AN - SCOPUS:0029098894

SN - 0925-4927

VL - 61

SP - 85

EP - 93

JO - Psychiatry Research: Neuroimaging

JF - Psychiatry Research: Neuroimaging

IS - 2

ER -

Regional differentiation of cortical activity in schizophrenia: a complementary approach to conventional analysis of regional cerebral blood flow

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this