Regional differentiation of cortical activity in schizophrenia

a complementary approach to conventional analysis of regional cerebral blood flow

Stephen Hook*, Evian Gordon, Ilario Lazzaro, Christine Burke, John Anderson, Yvonne Zurynski, Jeff Snars, Russell Meares

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study examines an alternative to a narrow locus-of-dysfunction cortical pathophysiology in schizophrenia, which in turn suggests a modified approach to the analysis of data from regional cerebral blood flow studies. The results provide qualified support for a model of impaired differentiation of cortical activity in schizophrenia. As an index of the differentiation of cortical fields, regional gradients of cortical blood flow were examined. Medicated patients (n = 15) failed to show the differentiation of networks in frontal areas during a verbal memory recognition task observed in normal comparison subjects (n = 15). Unmedicated patients (n = 15) at rest tended to lose normal lateralization and had increased gradients in the right frontal area compared with normal comparison subjects.

Original languageEnglish
Pages (from-to)85-93
Number of pages9
JournalPsychiatry Research: Neuroimaging
Volume61
Issue number2
DOIs
Publication statusPublished - 8 Aug 1995
Externally publishedYes

Keywords

  • Cortex
  • Differentiation
  • Pathophysiology
  • RCBF
  • Schizophrenia

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