Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study

Aleksandr Voskoboinik, Benedict T. Costello, Elana Kalman, Sandeep Prabhu, Hariharan Sugumar, Geoff Wong, Chrishan Nalliah, Liang-Han Ling, Alex McLellan, Thushan Hettige, Fabian Springer, Andre La Gerche, Jonathan M. Kalman, Andrew J Taylor, Peter M. Kistler

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function.

BACKGROUND: Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation.

METHODS: This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus rhythm. Patients self-reported alcohol consumption in standard drinks (∼12 g alcohol) per week over the preceding 12 months and were categorized into 4 groups: 1) lifelong nondrinkers; 2) mild drinkers (3 to 10 standard drinks/week); 3) moderate drinkers (11 to 20 standard drinks/week); 4) heavy drinkers (>20 standard drinks/week). Permanent AF and cardiomyopathy were excluded. On CMR, maximum LA volume (LAmax) and minimum LA volume (LAmin), global LA emptying fraction (LAEF) as (LAmax - LAmin) / LAmax, and LA reservoir function as (LAmax - LAmin) / LAmin were calculated.

RESULTS: Regular alcohol consumption (mean 15.8 ± 6.9 standard drinks/week, n = 120) was associated with larger LA size (LA volume index 50 ± 13 ml/m2 vs. 43 ± 12 ml/m2; p = 0.005), reduction in LAEF (40 ± 14% vs. 52 ± 15%; p < 0.001), and reduction in reservoir function (77 ± 48% vs. 119 ± 63%; p < 0.001) compared with lifelong nondrinkers (n = 40). There were progressive dose-related impairments in LAEF (mild 45.4 ± 13.5% vs. moderate 39.1 ± 14.7% vs. heavy drinkers 35.6 ± 12.6%; p < 0.01) and reservoir function (mild 95.8 ± 55.6% vs. moderate 74.8 ± 47.1% vs. heavy drinkers 61.7 ± 34.4%; p < 0.01). Predictors of atrial mechanical dysfunction included weekly alcohol intake (p = 0.001), older age (p = 0.018), and persistent AF (p = 0.016), but not binge drinking or beverage type.

CONCLUSIONS: In patients with AF, habitual alcohol consumption is associated with significantly increased LA size and atrial mechanical dysfunction compared with nondrinkers.

Original languageEnglish
Pages (from-to)1451-1459
Number of pages9
JournalJACC: Clinical Electrophysiology
Volume4
Issue number11
DOIs
Publication statusPublished - Nov 2018
Externally publishedYes

Keywords

  • alcohol
  • atrial fibrillation
  • atrial myopathy
  • cardiac magnetic resonance
  • left atrium

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