Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study

Aleksandr Voskoboinik; Benedict T. Costello; Elana Kalman; Sandeep Prabhu; Hariharan Sugumar; Geoff Wong; Chrishan Nalliah; Liang-Han Ling; Alex McLellan; Thushan Hettige; Fabian Springer; Andre La Gerche; Jonathan M. Kalman; Andrew J Taylor; Peter M. Kistler

doi:10.1016/j.jacep.2018.07.010

Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study

Aleksandr Voskoboinik, Benedict T. Costello, Elana Kalman, Sandeep Prabhu, Hariharan Sugumar, Geoff Wong, Chrishan Nalliah, Liang-Han Ling, Alex McLellan, Thushan Hettige, Fabian Springer, Andre La Gerche, Jonathan M. Kalman, Andrew J Taylor, Peter M. Kistler

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

OBJECTIVES: This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function.

BACKGROUND: Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation.

METHODS: This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus rhythm. Patients self-reported alcohol consumption in standard drinks (∼12 g alcohol) per week over the preceding 12 months and were categorized into 4 groups: 1) lifelong nondrinkers; 2) mild drinkers (3 to 10 standard drinks/week); 3) moderate drinkers (11 to 20 standard drinks/week); 4) heavy drinkers (>20 standard drinks/week). Permanent AF and cardiomyopathy were excluded. On CMR, maximum LA volume (LAmax) and minimum LA volume (LAmin), global LA emptying fraction (LAEF) as (LAmax - LAmin) / LAmax, and LA reservoir function as (LAmax - LAmin) / LAmin were calculated.

RESULTS: Regular alcohol consumption (mean 15.8 ± 6.9 standard drinks/week, n = 120) was associated with larger LA size (LA volume index 50 ± 13 ml/m2 vs. 43 ± 12 ml/m2; p = 0.005), reduction in LAEF (40 ± 14% vs. 52 ± 15%; p < 0.001), and reduction in reservoir function (77 ± 48% vs. 119 ± 63%; p < 0.001) compared with lifelong nondrinkers (n = 40). There were progressive dose-related impairments in LAEF (mild 45.4 ± 13.5% vs. moderate 39.1 ± 14.7% vs. heavy drinkers 35.6 ± 12.6%; p < 0.01) and reservoir function (mild 95.8 ± 55.6% vs. moderate 74.8 ± 47.1% vs. heavy drinkers 61.7 ± 34.4%; p < 0.01). Predictors of atrial mechanical dysfunction included weekly alcohol intake (p = 0.001), older age (p = 0.018), and persistent AF (p = 0.016), but not binge drinking or beverage type.

CONCLUSIONS: In patients with AF, habitual alcohol consumption is associated with significantly increased LA size and atrial mechanical dysfunction compared with nondrinkers.

Original language	English
Pages (from-to)	1451-1459
Number of pages	9
Journal	JACC: Clinical Electrophysiology
Volume	4
Issue number	11
DOIs	https://doi.org/10.1016/j.jacep.2018.07.010
Publication status	Published - Nov 2018
Externally published	Yes

Keywords

alcohol
atrial fibrillation
atrial myopathy
cardiac magnetic resonance
left atrium

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10.1016/j.jacep.2018.07.010

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Voskoboinik, A., Costello, B. T., Kalman, E., Prabhu, S., Sugumar, H., Wong, G., Nalliah, C., Ling, L.-H., McLellan, A., Hettige, T., Springer, F., La Gerche, A., Kalman, J. M., Taylor, A. J., & Kistler, P. M. (2018). Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study. JACC: Clinical Electrophysiology, 4(11), 1451-1459. https://doi.org/10.1016/j.jacep.2018.07.010

@article{7dc0f89f1e3e421caafe6b8e7598875e,

title = "Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study",

abstract = "OBJECTIVES: This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function.BACKGROUND: Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation.METHODS: This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus rhythm. Patients self-reported alcohol consumption in standard drinks (∼12 g alcohol) per week over the preceding 12 months and were categorized into 4 groups: 1) lifelong nondrinkers; 2) mild drinkers (3 to 10 standard drinks/week); 3) moderate drinkers (11 to 20 standard drinks/week); 4) heavy drinkers (>20 standard drinks/week). Permanent AF and cardiomyopathy were excluded. On CMR, maximum LA volume (LAmax) and minimum LA volume (LAmin), global LA emptying fraction (LAEF) as (LAmax - LAmin) / LAmax, and LA reservoir function as (LAmax - LAmin) / LAmin were calculated.RESULTS: Regular alcohol consumption (mean 15.8 ± 6.9 standard drinks/week, n = 120) was associated with larger LA size (LA volume index 50 ± 13 ml/m2 vs. 43 ± 12 ml/m2; p = 0.005), reduction in LAEF (40 ± 14\% vs. 52 ± 15\%; p < 0.001), and reduction in reservoir function (77 ± 48\% vs. 119 ± 63\%; p < 0.001) compared with lifelong nondrinkers (n = 40). There were progressive dose-related impairments in LAEF (mild 45.4 ± 13.5\% vs. moderate 39.1 ± 14.7\% vs. heavy drinkers 35.6 ± 12.6\%; p < 0.01) and reservoir function (mild 95.8 ± 55.6\% vs. moderate 74.8 ± 47.1\% vs. heavy drinkers 61.7 ± 34.4\%; p < 0.01). Predictors of atrial mechanical dysfunction included weekly alcohol intake (p = 0.001), older age (p = 0.018), and persistent AF (p = 0.016), but not binge drinking or beverage type.CONCLUSIONS: In patients with AF, habitual alcohol consumption is associated with significantly increased LA size and atrial mechanical dysfunction compared with nondrinkers.",

keywords = "alcohol, atrial fibrillation, atrial myopathy, cardiac magnetic resonance, left atrium",

author = "Aleksandr Voskoboinik and Costello, \{Benedict T.\} and Elana Kalman and Sandeep Prabhu and Hariharan Sugumar and Geoff Wong and Chrishan Nalliah and Liang-Han Ling and Alex McLellan and Thushan Hettige and Fabian Springer and \{La Gerche\}, Andre and Kalman, \{Jonathan M.\} and Taylor, \{Andrew J\} and Kistler, \{Peter M.\}",

year = "2018",

month = nov,

doi = "10.1016/j.jacep.2018.07.010",

language = "English",

volume = "4",

pages = "1451--1459",

journal = "JACC: Clinical Electrophysiology",

issn = "2405-5018",

publisher = "Elsevier",

number = "11",

}

Voskoboinik, A, Costello, BT, Kalman, E, Prabhu, S, Sugumar, H, Wong, G, Nalliah, C, Ling, L-H, McLellan, A, Hettige, T, Springer, F, La Gerche, A, Kalman, JM, Taylor, AJ & Kistler, PM 2018, 'Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study', JACC: Clinical Electrophysiology, vol. 4, no. 11, pp. 1451-1459. https://doi.org/10.1016/j.jacep.2018.07.010

Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study. / Voskoboinik, Aleksandr; Costello, Benedict T.; Kalman, Elana et al.
In: JACC: Clinical Electrophysiology, Vol. 4, No. 11, 11.2018, p. 1451-1459.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population

T2 - a cross-sectional MRI-based study

AU - Voskoboinik, Aleksandr

AU - Costello, Benedict T.

AU - Kalman, Elana

AU - Prabhu, Sandeep

AU - Sugumar, Hariharan

AU - Wong, Geoff

AU - Nalliah, Chrishan

AU - Ling, Liang-Han

AU - McLellan, Alex

AU - Hettige, Thushan

AU - Springer, Fabian

AU - La Gerche, Andre

AU - Kalman, Jonathan M.

AU - Taylor, Andrew J

AU - Kistler, Peter M.

PY - 2018/11

Y1 - 2018/11

N2 - OBJECTIVES: This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function.BACKGROUND: Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation.METHODS: This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus rhythm. Patients self-reported alcohol consumption in standard drinks (∼12 g alcohol) per week over the preceding 12 months and were categorized into 4 groups: 1) lifelong nondrinkers; 2) mild drinkers (3 to 10 standard drinks/week); 3) moderate drinkers (11 to 20 standard drinks/week); 4) heavy drinkers (>20 standard drinks/week). Permanent AF and cardiomyopathy were excluded. On CMR, maximum LA volume (LAmax) and minimum LA volume (LAmin), global LA emptying fraction (LAEF) as (LAmax - LAmin) / LAmax, and LA reservoir function as (LAmax - LAmin) / LAmin were calculated.RESULTS: Regular alcohol consumption (mean 15.8 ± 6.9 standard drinks/week, n = 120) was associated with larger LA size (LA volume index 50 ± 13 ml/m2 vs. 43 ± 12 ml/m2; p = 0.005), reduction in LAEF (40 ± 14% vs. 52 ± 15%; p < 0.001), and reduction in reservoir function (77 ± 48% vs. 119 ± 63%; p < 0.001) compared with lifelong nondrinkers (n = 40). There were progressive dose-related impairments in LAEF (mild 45.4 ± 13.5% vs. moderate 39.1 ± 14.7% vs. heavy drinkers 35.6 ± 12.6%; p < 0.01) and reservoir function (mild 95.8 ± 55.6% vs. moderate 74.8 ± 47.1% vs. heavy drinkers 61.7 ± 34.4%; p < 0.01). Predictors of atrial mechanical dysfunction included weekly alcohol intake (p = 0.001), older age (p = 0.018), and persistent AF (p = 0.016), but not binge drinking or beverage type.CONCLUSIONS: In patients with AF, habitual alcohol consumption is associated with significantly increased LA size and atrial mechanical dysfunction compared with nondrinkers.

AB - OBJECTIVES: This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function.BACKGROUND: Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation.METHODS: This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus rhythm. Patients self-reported alcohol consumption in standard drinks (∼12 g alcohol) per week over the preceding 12 months and were categorized into 4 groups: 1) lifelong nondrinkers; 2) mild drinkers (3 to 10 standard drinks/week); 3) moderate drinkers (11 to 20 standard drinks/week); 4) heavy drinkers (>20 standard drinks/week). Permanent AF and cardiomyopathy were excluded. On CMR, maximum LA volume (LAmax) and minimum LA volume (LAmin), global LA emptying fraction (LAEF) as (LAmax - LAmin) / LAmax, and LA reservoir function as (LAmax - LAmin) / LAmin were calculated.RESULTS: Regular alcohol consumption (mean 15.8 ± 6.9 standard drinks/week, n = 120) was associated with larger LA size (LA volume index 50 ± 13 ml/m2 vs. 43 ± 12 ml/m2; p = 0.005), reduction in LAEF (40 ± 14% vs. 52 ± 15%; p < 0.001), and reduction in reservoir function (77 ± 48% vs. 119 ± 63%; p < 0.001) compared with lifelong nondrinkers (n = 40). There were progressive dose-related impairments in LAEF (mild 45.4 ± 13.5% vs. moderate 39.1 ± 14.7% vs. heavy drinkers 35.6 ± 12.6%; p < 0.01) and reservoir function (mild 95.8 ± 55.6% vs. moderate 74.8 ± 47.1% vs. heavy drinkers 61.7 ± 34.4%; p < 0.01). Predictors of atrial mechanical dysfunction included weekly alcohol intake (p = 0.001), older age (p = 0.018), and persistent AF (p = 0.016), but not binge drinking or beverage type.CONCLUSIONS: In patients with AF, habitual alcohol consumption is associated with significantly increased LA size and atrial mechanical dysfunction compared with nondrinkers.

KW - alcohol

KW - atrial fibrillation

KW - atrial myopathy

KW - cardiac magnetic resonance

KW - left atrium

UR - https://www.scopus.com/pages/publications/85057128234

U2 - 10.1016/j.jacep.2018.07.010

DO - 10.1016/j.jacep.2018.07.010

M3 - Article

C2 - 30466852

SN - 2405-5018

VL - 4

SP - 1451

EP - 1459

JO - JACC: Clinical Electrophysiology

JF - JACC: Clinical Electrophysiology

IS - 11

ER -

Regular alcohol consumption is associated with impaired atrial mechanical function in the atrial fibrillation population: a cross-sectional MRI-based study

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