Regulation of brain-derived neurotrophic factor and growth factor signaling pathways by tyrosine phosphatase Shp2 in the retina: a brief review

Mojdeh Abbasi*, Vivek Gupta, Nitin Chitranshi, Yuyi You, Yogita Dheer, Mehdi Mirzaei, Stuart L. Graham

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

20 Citations (Scopus)
15 Downloads (Pure)

Abstract

SH2 domain-containing tyrosine phosphatase-2 (PTPN11 or Shp2) is a ubiquitously expressed protein that plays a key regulatory role in cell proliferation, differentiation and growth factor (GF) signaling. This enzyme is well expressed in various retinal neurons and has emerged as an important player in regulating survival signaling networks in the neuronal tissues. The non-receptor phosphatase can translocate to lipid rafts in the membrane and has been implicated to regulate several signaling modules including PI3K/Akt, JAK-STAT and Mitogen Activated Protein Kinase (MAPK) pathways in a wide range of biochemical processes in healthy and diseased states. This review focuses on the roles of Shp2 phosphatase in regulating brain-derived neurotrophic factor (BDNF) neurotrophin signaling pathways and discusses its cross-talk with various GF and downstream signaling pathways in the retina.

Original languageEnglish
Article number85
Pages (from-to)1-10
Number of pages10
JournalFrontiers in Cellular Neuroscience
Volume12
DOIs
Publication statusPublished - 27 Mar 2018

Bibliographical note

Copyright the Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • BDNF neurotrophin
  • Growth factors
  • Retina
  • Shp2 phosphatase
  • TrkB receptor

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