Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract

Osamu Takikawa, Tamantha Littlejohn, Joanne F. Jamie, Mark J. Walker, Roger J. W. Truscott

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Citations (Scopus)

Abstract

3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H2O2, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials. Thus, if 3OHkyn can be shown to be the causative agent in cataract, it may be possible to prevent the disease by lowering the level of 3OHKyn. To this end, indoleamine 2,3-dioxygenase, the first enzyme in UV filter synthesis, was studied using lens epithelial cell lines. The results indicated that the IDO expression is mediated by IFN-γ. Immuno-suppressants which inhibit production of IFN-γ may act as anti-cataract agents. Another way to lower the level of 3OHKyn is to use specific inhibitors for IDO. A recombinant human IDO was expressed to develop the inhibitors.

Original languageEnglish
Title of host publicationTryptophan, serotonin, and melatonin
Subtitle of host publicationbasic aspects and applications
Place of PublicationNew York
PublisherSpringer, Springer Nature
Pages241-245
Number of pages5
ISBN (Electronic)9781461547099
ISBN (Print)9781461371335
DOIs
Publication statusPublished - 1999
Externally publishedYes
EventNinth Meeting of the "International Study Group for Tryptophan Research" (lSTRY) - University of Hamburg, Hamburg, Germany
Duration: 10 Oct 199814 Oct 1998

Publication series

NameAdvances in experimental medicine and biology
PublisherSpringer
Volume467
ISSN (Print)0065-2598

Conference

ConferenceNinth Meeting of the "International Study Group for Tryptophan Research" (lSTRY)
CountryGermany
CityHamburg
Period10/10/9814/10/98

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