Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract

Osamu Takikawa; Tamantha Littlejohn; Joanne F. Jamie; Mark J. Walker; Roger J. W. Truscott

doi:10.1007/978-1-4615-4709-9_31

Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract

Osamu Takikawa, Tamantha Littlejohn, Joanne F. Jamie, Mark J. Walker, Roger J. W. Truscott

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

11 Citations (Scopus)

Abstract

3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H₂O₂, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials. Thus, if 3OHkyn can be shown to be the causative agent in cataract, it may be possible to prevent the disease by lowering the level of 3OHKyn. To this end, indoleamine 2,3-dioxygenase, the first enzyme in UV filter synthesis, was studied using lens epithelial cell lines. The results indicated that the IDO expression is mediated by IFN-γ. Immuno-suppressants which inhibit production of IFN-γ may act as anti-cataract agents. Another way to lower the level of 3OHKyn is to use specific inhibitors for IDO. A recombinant human IDO was expressed to develop the inhibitors.

Original language	English
Title of host publication	Tryptophan, serotonin, and melatonin
Subtitle of host publication	basic aspects and applications
Place of Publication	New York
Publisher	Springer, Springer Nature
Pages	241-245
Number of pages	5
ISBN (Electronic)	9781461547099
ISBN (Print)	9781461371335
DOIs	https://doi.org/10.1007/978-1-4615-4709-9_31
Publication status	Published - 1999
Externally published	Yes
Event	Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY) - University of Hamburg, Hamburg, Germany Duration: 10 Oct 1998 → 14 Oct 1998

Publication series

Name	Advances in experimental medicine and biology
Publisher	Springer
Volume	467
ISSN (Print)	0065-2598

Conference

Conference	Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY)
Country/Territory	Germany
City	Hamburg
Period	10/10/98 → 14/10/98

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10.1007/978-1-4615-4709-9_31

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Takikawa, O., Littlejohn, T., Jamie, J. F., Walker, M. J., & Truscott, R. J. W. (1999). Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract. In Tryptophan, serotonin, and melatonin: basic aspects and applications (pp. 241-245). (Advances in experimental medicine and biology; Vol. 467). Springer, Springer Nature. https://doi.org/10.1007/978-1-4615-4709-9_31

Takikawa, Osamu ; Littlejohn, Tamantha ; Jamie, Joanne F. et al. / Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens : relevance for senile nuclear cataract. Tryptophan, serotonin, and melatonin: basic aspects and applications. New York : Springer, Springer Nature, 1999. pp. 241-245 (Advances in experimental medicine and biology).

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title = "Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract",

abstract = "3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H2O2, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials. Thus, if 3OHkyn can be shown to be the causative agent in cataract, it may be possible to prevent the disease by lowering the level of 3OHKyn. To this end, indoleamine 2,3-dioxygenase, the first enzyme in UV filter synthesis, was studied using lens epithelial cell lines. The results indicated that the IDO expression is mediated by IFN-γ. Immuno-suppressants which inhibit production of IFN-γ may act as anti-cataract agents. Another way to lower the level of 3OHKyn is to use specific inhibitors for IDO. A recombinant human IDO was expressed to develop the inhibitors.",

author = "Osamu Takikawa and Tamantha Littlejohn and Jamie, {Joanne F.} and Walker, {Mark J.} and Truscott, {Roger J. W.}",

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Takikawa, O, Littlejohn, T, Jamie, JF, Walker, MJ & Truscott, RJW 1999, Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract. in Tryptophan, serotonin, and melatonin: basic aspects and applications. Advances in experimental medicine and biology, vol. 467, Springer, Springer Nature, New York, pp. 241-245, Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), Hamburg, Germany, 10/10/98. https://doi.org/10.1007/978-1-4615-4709-9_31

Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract. / Takikawa, Osamu; Littlejohn, Tamantha; Jamie, Joanne F. et al.
Tryptophan, serotonin, and melatonin: basic aspects and applications. New York: Springer, Springer Nature, 1999. p. 241-245 (Advances in experimental medicine and biology; Vol. 467).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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T1 - Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens

T2 - Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY)

AU - Takikawa, Osamu

AU - Littlejohn, Tamantha

AU - Jamie, Joanne F.

AU - Walker, Mark J.

AU - Truscott, Roger J. W.

PY - 1999

Y1 - 1999

N2 - 3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H2O2, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials. Thus, if 3OHkyn can be shown to be the causative agent in cataract, it may be possible to prevent the disease by lowering the level of 3OHKyn. To this end, indoleamine 2,3-dioxygenase, the first enzyme in UV filter synthesis, was studied using lens epithelial cell lines. The results indicated that the IDO expression is mediated by IFN-γ. Immuno-suppressants which inhibit production of IFN-γ may act as anti-cataract agents. Another way to lower the level of 3OHKyn is to use specific inhibitors for IDO. A recombinant human IDO was expressed to develop the inhibitors.

AB - 3-Hydroxykynurenine (3OHKyn), the precursor of UV filters in human lens, is highly autooxidizable, generates H2O2, and binds to lens proteins, yielding a tanned/yellow product resembling senile nuclear cataractous materials. Thus, if 3OHkyn can be shown to be the causative agent in cataract, it may be possible to prevent the disease by lowering the level of 3OHKyn. To this end, indoleamine 2,3-dioxygenase, the first enzyme in UV filter synthesis, was studied using lens epithelial cell lines. The results indicated that the IDO expression is mediated by IFN-γ. Immuno-suppressants which inhibit production of IFN-γ may act as anti-cataract agents. Another way to lower the level of 3OHKyn is to use specific inhibitors for IDO. A recombinant human IDO was expressed to develop the inhibitors.

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AN - SCOPUS:0034466508

SN - 9781461371335

T3 - Advances in experimental medicine and biology

SP - 241

EP - 245

BT - Tryptophan, serotonin, and melatonin

PB - Springer, Springer Nature

CY - New York

Y2 - 10 October 1998 through 14 October 1998

ER -

Takikawa O, Littlejohn T, Jamie JF, Walker MJ, Truscott RJW. Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract. In Tryptophan, serotonin, and melatonin: basic aspects and applications. New York: Springer, Springer Nature. 1999. p. 241-245. (Advances in experimental medicine and biology). doi: 10.1007/978-1-4615-4709-9_31

Regulation of indoleamine 2,3-dioxygenase, the first enzyme in UV filter biosynthesis in the human lens: relevance for senile nuclear cataract

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