Regulation of the cytoskeleton assembly: a role for a ternary complex of actin with two actin-binding proteins

Murat Kekic*, Neil J. Nosworthy, Irina Dedova, Charles A. Collyer, Cristobal G. dos Remedios

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The actin cytoskeleton is an essential component of all eukaryotic cells. Besides its role in cell motility, it has a number of other functions, including cytokinesis, signal transduction, and the maintenance of cell shape. An essential property of the cytoskeleton is its ability to rapidly assemble and disassemble monomers of actin into F-actin filaments and this process is now known to be regulated by a number of actin-binding proteins (ABPs) of which cofilin appears to be the most widely distributed in nature. In this chapter we pose the question: does cofilin act alone in controlling actin filament assembly or is the binding of cofilin to actin modulated by other ABPs?
Original languageEnglish
Title of host publicationMolecular Interactions of Actin
Subtitle of host publicationActin Structure and Actin-Binding Proteins
Place of PublicationCham, Switzerland
PublisherSpringer, Springer Nature
Pages165-179
Number of pages15
ISBN (Electronic)9783540465607
ISBN (Print)9783642536755
DOIs
Publication statusPublished - 2001
Externally publishedYes

Publication series

NameResults and problems in cell differentiation
PublisherSpringer, Springer Nature
ISSN (Print)0080-1844
Name
Volume32

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