Regulation of the postsynaptic compartment of excitatory synapses by the actin cytoskeleton in health and its disruption in disease

Holly Stefen, Chanchanok Chaichim, John Power, Thomas Fath*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)
18 Downloads (Pure)

Abstract

Disruption of synaptic function at excitatory synapses is one of the earliest pathological changes seen in wide range of neurological diseases. The proper control of the segregation of neurotransmitter receptors at these synapses is directly correlated with the intact regulation of the postsynaptic cytoskeleton. In this review, we are discussing key factors that regulate the structure and dynamics of the actin cytoskeleton, the major cytoskeletal building block that supports the postsynaptic compartment. Special attention is given to the complex interplay of actin-associated proteins that are found in the synaptic specialization. We then discuss our current understanding of how disruption of these cytoskeletal elements may contribute to the pathological events observed in the nervous system under disease conditions with a particular focus on Alzheimer's disease pathology.

Original languageEnglish
Article number2371970
Pages (from-to)1-19
Number of pages19
JournalNeural Plasticity
Volume2016
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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