Regulators of adult neurogenesis in the healthy and diseased brain

Helen E. Grote, Anthony J. Hannan*

*Corresponding author for this work

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

1. In recent decades evidence has accumulated demonstrating the birth and functional integration of new neurons in specific regions of the adult mammalian brain, including the dentate gyrus of the hippocampus and the subventricular zone. 2. Studies in a variety of models have revealed genetic, environmental and pharmacological factors that regulate adult neurogenesis. The present review examines some of the molecular and cellular mechanisms that could be mediating these regulatory effects in both the normal and dysfunctional brain. 3. The dysregulation of adult neurogenesis may contribute to the pathogenesis of neurodegenerative disorders, such as Huntington's, Alzheimer's and Parkinson's disease, as well as psychiatric disorders such as depresssion. Recent evidence supports this idea and, furthermore, also indicates that factors promoting neurogenesis can modify the onset and progression of specific brain disorders, including Huntington's disease and depression.

Original languageEnglish
Pages (from-to)533-545
Number of pages13
JournalClinical and Experimental Pharmacology and Physiology
Volume34
Issue number5-6
DOIs
Publication statusPublished - May 2007
Externally publishedYes

Keywords

  • Brain injury
  • Dementia
  • Dentate gyrus
  • Depression
  • Hippocampus
  • Huntington's disease
  • Neural stem cells
  • Neurodegenerative disease
  • Psychiatric disorders
  • Subventricular zone

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