Regulatory immune cells in kidney disease

V. W. S. Lee*, Y. M. Wang, Y. P. Wang, D. Zheng, T. Polhill, Q. Cao, H. Wu, I. E. Alexander, S. I. Alexander, D. C. H. Harris

*Corresponding author for this work

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Lymphocytes and macrophages act as effector immune cells in the initiation and progression of renal injury. Recent data have shown that subpopulations of these immune cells (regulatory T lymphocytes and alternately-activated or regulatory macrophages) are potent modulators of tissue injury and repair in renal disease. Recent animal studies examining the therapeutic effect of these cells raise the exciting possibility that strategies targeting these cell types may be effective in treating and preventing kidney disease in humans. This review will describe their biological role in experimental kidney disease and therapeutic potential in clinical nephrology.

Original languageEnglish
Pages (from-to)F335-F342
Number of pages8
JournalAmerican Journal of Physiology - Renal Physiology
Volume295
Issue number2
DOIs
Publication statusPublished - 1 Aug 2008
Externally publishedYes

Keywords

  • regulatory T lymphocytes
  • FoxP3
  • macrophages
  • dendritic cells
  • immunotherapy
  • MURINE ADRIAMYCIN NEPHROPATHY
  • BASEMENT-MEMBRANE GLOMERULONEPHRITIS
  • TRANSCRIPTION FACTOR FOXP3
  • POSITIVE DENDRITIC CELLS
  • CD4(+) T-CELLS
  • RENAL INJURY
  • CUTTING EDGE
  • MAST-CELLS
  • CRESCENTIC GLOMERULONEPHRITIS
  • GLOMERULAR INJURY

Cite this

Lee, V. W. S., Wang, Y. M., Wang, Y. P., Zheng, D., Polhill, T., Cao, Q., ... Harris, D. C. H. (2008). Regulatory immune cells in kidney disease. American Journal of Physiology - Renal Physiology, 295(2), F335-F342. https://doi.org/10.1152/ajprenal.00077.2008