Relationship between angiographic infarct size and left ventricular filling

Richard Cranswick*, Robyn Davis, Michael Jones, Stephen N. Hunyor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Infarct size may influence left ventricular filling after acute myocardial infarction. Pulsed Doppler transmitral flow velocities were compared in 47 patients at 7 ± 6 days following acute myocardial infarction and 47 age-matched controls. Patients were stratified by angiographic infarct size into Groups I, II, III (corresponding angiographic hypokinetic scores < 2; 2-2.99; ≥ 3 SD/cord). Early diastolic transmitral Doppler flow velocities did not differ between infarct groups but atrial transmitral Doppler flow measurements did: peak A velocity (p = 0.001), A velocity time integral (p < 0.001), and total velocity time integral (p = 0.001). Compared to controls atrial transmitral Doppler flow was augmented in Group I, whilst atrial and total transmitral Doppler flow were depressed in Group III. Peak A velocity and A velocity time integral were inversely related to infarct size (R = -0.44 to -0.54) and directly to left ventricular ejection fraction (R = 0.59 to 0.65). Large infarct size following myocardial infarction is associated with lower atrial and total transmitral Doppler flow velocities.

Original languageEnglish
Pages (from-to)241-251
Number of pages11
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - 1992
Externally publishedYes


  • Atrial contribution
  • Hyperkinesis
  • Hypokinesis
  • Left ventricular ejection fraction


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