Relationship between Heart Rate Variability and angiotensinogen gene polymorphism in diabetic and control individuals

Faezeh Marzbanrad, Brett Hambly, Ethan Ng, Mikhail Tamayo, Slade Matthews, Chandan Karmakar, Ahasan H. Khandoker, Marimuthu Palaniswami, Herbert F. Jelinek

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

    2 Citations (Scopus)

    Abstract

    Heart Rate Variability (HRV) is extensively used to investigate general Autonomic Nervous System (ANS) function and is affected by many factors including age, gender, pathology such as diabetes and genetic polymorphisms. One of these genetic polymorphisms is the Angiotensin Converting Enzyme (ACE) polymorphism corresponding to insertion (I) or deletion (D) of a 287-base pair sequence of DNA in intron 16 of the ACE gene (rs4340). Some studies have addressed the relationship between HRV and D/D, I/D and I/I ACE polymorphism while others combined I/D and I/I ACE groups. In this study HRV is determined for diabetic and control individuals with different ACE polymorphism considering either separate or combined I/D and I/I genotypes. Linear time domain parameters, entropy, low frequency and total power of HRV were found to be significantly different between diabetic and control individuals with combined I/I and I/D ACE polymorphism, while only entropy was different for diabetic and control subjects with D/D ACE genotype. Separate analysis of I/I and I/D genotypes was preferred for a thorough investigation of HRV and ACE polymorphism, as the combined analysis masked some differences in HRV parameters such as Poincaré plot between ACE polymorphisms and diabetes status. Furthermore, a separate analysis demonstrated that most of the significant differences for HRV were between the diabetic group with I/I genotype and I/D and D/D groups.
    Original languageEnglish
    Title of host publicationEMBC 2014
    Subtitle of host publication36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society : Proceedings
    Place of PublicationPiscataway, NJ
    PublisherInstitute of Electrical and Electronics Engineers (IEEE)
    Pages6683-6686
    Number of pages4
    ISBN (Print)9781424479290
    DOIs
    Publication statusPublished - 2 Nov 2014
    EventAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (36th : 2014) - Chicago, IL
    Duration: 26 Aug 201430 Aug 2014

    Conference

    ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (36th : 2014)
    CityChicago, IL
    Period26/08/1430/08/14

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