Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

Stephan Müller; Oliver Preische; Hamid R. Sohrabi; Susanne Gräber; Mathias Jucker; John M. Ringman; Ralph N. Martins; Eric McDade; Peter R. Schofield; Bernardino Ghetti; Martin Rossor; Nick N. Fox; Neill R. Graff-Radford; Johannes Levin; Adrian Danek; Jonathan Vöglein; Stephen Salloway; Chengjie Xiong; Tammie Benzinger; Virginia Buckles; Colin L. Masters; Reisa Sperling; Randall J. Bateman; John C. Morris; Christoph Laske; Dominantly Inherited Alzheimer Network (DIAN)

doi:10.1016/j.jalz.2018.06.3059

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

Stephan Müller, Oliver Preische, Hamid R. Sohrabi, Susanne Gräber, Mathias Jucker, John M. Ringman, Ralph N. Martins, Eric McDade, Peter R. Schofield, Bernardino Ghetti, Martin Rossor, Nick N. Fox, Neill R. Graff-Radford, Johannes Levin, Adrian Danek, Jonathan Vöglein, Stephen Salloway, Chengjie Xiong, Tammie Benzinger, Virginia BucklesColin L. Masters, Reisa Sperling, Randall J. Bateman, John C. Morris, Christoph Laske, Dominantly Inherited Alzheimer Network (DIAN)

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Introduction: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). Methods: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. Results: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. Discussion: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.

Original language	English
Pages (from-to)	1427-1437
Number of pages	11
Journal	Alzheimer's and Dementia
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.jalz.2018.06.3059
Publication status	Published - 1 Nov 2018

Keywords

Cerebrospinal fluid biomarkers
Cognitive function
Dominantly inherited Alzheimer's disease
Functional status
Mutation carrier
Physical activity

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Müller, S., Preische, O., Sohrabi, H. R., Gräber, S., Jucker, M., Ringman, J. M., Martins, R. N., McDade, E., Schofield, P. R., Ghetti, B., Rossor, M., Fox, N. N., Graff-Radford, N. R., Levin, J., Danek, A., Vöglein, J., Salloway, S., Xiong, C., Benzinger, T., ... Dominantly Inherited Alzheimer Network (DIAN) (2018). Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's and Dementia, 14(11), 1427-1437. https://doi.org/10.1016/j.jalz.2018.06.3059

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title = "Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease",

abstract = "Introduction: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). Methods: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. Results: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. Discussion: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.",

keywords = "Cerebrospinal fluid biomarkers, Cognitive function, Dominantly inherited Alzheimer's disease, Functional status, Mutation carrier, Physical activity",

author = "Stephan M{\"u}ller and Oliver Preische and Sohrabi, {Hamid R.} and Susanne Gr{\"a}ber and Mathias Jucker and Ringman, {John M.} and Martins, {Ralph N.} and Eric McDade and Schofield, {Peter R.} and Bernardino Ghetti and Martin Rossor and Fox, {Nick N.} and Graff-Radford, {Neill R.} and Johannes Levin and Adrian Danek and Jonathan V{\"o}glein and Stephen Salloway and Chengjie Xiong and Tammie Benzinger and Virginia Buckles and Masters, {Colin L.} and Reisa Sperling and Bateman, {Randall J.} and Morris, {John C.} and Christoph Laske and {Dominantly Inherited Alzheimer Network (DIAN)}",

year = "2018",

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doi = "10.1016/j.jalz.2018.06.3059",

language = "English",

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Müller, S, Preische, O, Sohrabi, HR, Gräber, S, Jucker, M, Ringman, JM, Martins, RN, McDade, E, Schofield, PR, Ghetti, B, Rossor, M, Fox, NN, Graff-Radford, NR, Levin, J, Danek, A, Vöglein, J, Salloway, S, Xiong, C, Benzinger, T, Buckles, V, Masters, CL, Sperling, R, Bateman, RJ, Morris, JC, Laske, C & Dominantly Inherited Alzheimer Network (DIAN) 2018, 'Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease', Alzheimer's and Dementia, vol. 14, no. 11, pp. 1427-1437. https://doi.org/10.1016/j.jalz.2018.06.3059

TY - JOUR

T1 - Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

AU - Müller, Stephan

AU - Preische, Oliver

AU - Sohrabi, Hamid R.

AU - Gräber, Susanne

AU - Jucker, Mathias

AU - Ringman, John M.

AU - Martins, Ralph N.

AU - McDade, Eric

AU - Schofield, Peter R.

AU - Ghetti, Bernardino

AU - Rossor, Martin

AU - Fox, Nick N.

AU - Graff-Radford, Neill R.

AU - Levin, Johannes

AU - Danek, Adrian

AU - Vöglein, Jonathan

AU - Salloway, Stephen

AU - Xiong, Chengjie

AU - Benzinger, Tammie

AU - Buckles, Virginia

AU - Masters, Colin L.

AU - Sperling, Reisa

AU - Bateman, Randall J.

AU - Morris, John C.

AU - Laske, Christoph

AU - Dominantly Inherited Alzheimer Network (DIAN)

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Introduction: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). Methods: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. Results: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. Discussion: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.

AB - Introduction: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). Methods: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. Results: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. Discussion: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.

KW - Cerebrospinal fluid biomarkers

KW - Cognitive function

KW - Dominantly inherited Alzheimer's disease

KW - Functional status

KW - Mutation carrier

KW - Physical activity

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U2 - 10.1016/j.jalz.2018.06.3059

DO - 10.1016/j.jalz.2018.06.3059

M3 - Article

C2 - 30266303

AN - SCOPUS:85056312315

SN - 1552-5260

VL - 14

SP - 1427

EP - 1437

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 11

ER -

Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease

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Keywords

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