Relationship between serum high sensitivity C‐reactive protein with angiographic severity of coronary artery disease and traditional cardiovascular risk factors

Mohammad Tajfard, Seyedeh Belin Tavakoly Sany, Amir Avan, Latiffah A. Latiff, Hamid Reza Rahimi, Mohsen Moohebati, Medhi Hasanzadeh, Hamideh Ghazizadeh, Habibollah Esmaeily, Hassan Doosti, Ali Taghipour, Majid Ghayour-Mobarhan, Gordon A. Ferns, Marzie Emamian, Mohd Sokhini Bin Abd Mutalib

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    31 Citations (Scopus)

    Abstract

    Serum high-sensitivity C-reactive protein (hs-CRP) is predictive of coronary artery disease (CAD). The aim of this study was to examine the possible association of hs-CRP with presence and severity of CAD and traditional CAD risk factors. This case-control study was carried out on 2,346 individuals from September 2011 to May 2013. Of these 1,187 had evidence of coronary disease, and were subject to coronary angiography, and the remainder were healthy controls (n = 1,159). Characteristics were determined using standard laboratory techniques and serum Hs-CRP levels were estimated using enzyme-linked immunosorbent assay (ELISA) kits, and severity of CAD was assessed according to the score of obstruction in coronary artery. Serum hs-CRP levels were higher in those with severe coronary disease, who had stenosis ≥ 50% stenosis of at least one coronary artery (all p < 0.001 vs. individuals in healthy control), and correlated significantly with the score for coronary artery disease (all p < 0.01). After adjustment for conventional risk factors, regression analysis revealed that smoking habits, fasting blood glucose, total cholesterol, high-density lipoprotein, hs-CRP, blood pressure, anxiety, dietary intake of vitamin E, and cholesterol remained as independent determinants for angiographic severity of CAD. The area under the receiving operating characteristic (ROC) curve for serum hs-CRP was 0.869 (CI 95% 0.721–0.872, p < 0.001). The optimal values for the cut-off point was a serum hs-CRP of 2.78 mg/l (sensitivity 80.20%, specificity 85%) to predict severity of CAD. Increased serum hs-CRP levels are significantly associated with angiographic severity of CAD, suggesting its value as a biomarkers for predicting CAD.

    Original languageEnglish
    Pages (from-to)10289-10299
    Number of pages11
    JournalJournal of Cellular Physiology
    Volume234
    Issue number7
    Early online date12 Dec 2018
    DOIs
    Publication statusPublished - Jul 2019

    Keywords

    • angiography
    • biomarker
    • coronary artery disease
    • hs‐CRP
    • traditional risk factor
    • hs-CRP

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