Relationships between isometric and isotonic mechanical parameters and cross-bridge kinetics

Gunther H. Rossmanith*, Oka B. Tjokorda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


1. Isometric and isotonic measures have been widely used both to characterize muscular contraction in striated muscle and to compare the mechanical properties of striated muscle types for a wide variety of species. The interrelationship of these measures and their interpretation, in terms of underlying cross-bridge mechanisms, requires clarification. 2. We demonstrate that a strain-dependent three-state model can simulate these isometric and isotonic mechanics and offer a unified explanation for these mechanics in terms of crossbridge kinetics. 3. Our exploration reveals the partial view each individual measure of mechanics provides and emphasizes the complementary insights the various isometric and isotonic measures give of the underlying cross-bridge kinetics.

Original languageEnglish
Pages (from-to)522-535
Number of pages14
JournalClinical and Experimental Pharmacology and Physiology
Issue number7-8
Publication statusPublished - Aug 1998


  • force-velocity relationships
  • simulation
  • sinusoidal stiffness
  • strain-sensitive cross-bridge transitions
  • tension redevelopment
  • tension transients


Dive into the research topics of 'Relationships between isometric and isotonic mechanical parameters and cross-bridge kinetics'. Together they form a unique fingerprint.

Cite this