Relationships between performance on the cogstate brief battery, neurodegeneration, and aβ accumulation in cognitively normal older adults and adults with MCI

Yen Ying Lim*, Robert H. Pietrzak, Pierrick Bourgeat, David Ames, Kathryn A. Ellis, Alan Rembach, Karra Harrington, Olivier Salvado, Ralph N. Martins, Peter J. Snyder, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne, Paul Maruff

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = 178) and adults with mild cognitive impairment (MCI) (n = 49) underwent positron emission tomography neuroimaging, magnetic resonance imaging, and cognitive assessments at baseline, 18- and 36-months. Relative to Aβ- CNs, Aβ+ CNs and Aβ+ MCIs showed greater rates of cognitive decline, Aβ accumulation, and hippocampal atrophy. Analysis of interrelationships between these Alzheimer's disease markers in Aβ+ CNs and MCIs indicated that rate of Aβ accumulation was associated with rate of hippocampal atrophy (β = -0.05, p =.037), which was in turn associated independently with rate of decline in memory (β = -0.03, p =.032). This suggests that Aβ accumulation precedes any neurodegeneration or clinical symptoms, and that the relationship between Aβ and cognitive decline is mediated by hippocampal atrophy.

Original languageEnglish
Pages (from-to)49-58
Number of pages10
JournalArchives of Clinical Neuropsychology
Volume30
Issue number1
DOIs
Publication statusPublished - 1 Feb 2015
Externally publishedYes

Keywords

  • Episodic memory
  • Hippocampal volume
  • MCI
  • Neuropsychological assessment
  • Preclinical AD
  • β-amyloid

Fingerprint Dive into the research topics of 'Relationships between performance on the cogstate brief battery, neurodegeneration, and aβ accumulation in cognitively normal older adults and adults with MCI'. Together they form a unique fingerprint.

Cite this