Relevance of the anti-inflammatory properties of curcumin in neurodegenerative diseases and depression

Yousef Tizabi*, Laura L. Hurley, Zakiya Qualls, Luli Akinfiresoye

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

52 Citations (Scopus)
2 Downloads (Pure)

Abstract

This review is an attempt to summarize our current understanding of curcumin's potential as a neuroprotectant and an antidepressant. This dual property confers a unique advantage to this herbal medication, believed to be devoid of any major side effects, to combat commonly observed co-morbid conditions of a neurodegenerative and a neuropsychiatric disorder. Moreover, in line with the theme of this series, the role of inflammation and stress in these diseases and possible anti-inflammatory effects of curcumin, as well as its interaction with signal transduction proteins as a common denominator in its varied mechanisms of action, are also discussed. Thus, following a brief introduction of curcumin's pharmacology, we present research suggesting how its anti-inflammatory properties have therapeutic potential in treating a devastating neurological disorder (Parkinson's disease = PD) and a debilitating neuropsychiatric disorder (major depressive disorder = MDD). It is concluded that curcumin, or better yet, an analog with better and longer bioavailability could be of important therapeutic potential in PD and/or major depression.

Original languageEnglish
Pages (from-to)20864-20879
Number of pages16
JournalMolecules
Volume19
Issue number12
DOIs
Publication statusPublished - Dec 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • curcumin
  • inflammation
  • depression
  • Parkinson's disease
  • neuroprotection
  • Neuroprotection
  • Depression
  • Curcumin
  • Inflammation

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