Remitted but still impaired? Symptomatic versus functional remission in patients with schizophrenia

A. Karow*, S. Moritz, M. Lambert, D. Schöttle, D. Naber

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Introduction: Studies reported close associations between functional outcome and symptomatic remission as defined by the Remission in Schizophrenia Working Group. This observational study was aimed at the investigation of deficits in daily functioning, symptoms and subjective well-being in remitted and non-remitted patients with schizophrenia. Methods: Symptoms (PANSS), functional outcome (FROGS, GAF), subjective well-being (SWN-K) and other characteristics were assessed in 131 patients with schizophrenia (DSM-IV) within the European Group on Functional Outcomes and Remission in Schizophrenia (EGOFORS) project. Results: A significant better level of functioning was measured for remitted versus non-remitted patients, though remitted patients still showed areas with an inadequate level of functioning. Functional deficits were most often seen in social relations (40%), work (29%) and daily life activities (17%). Best functioning was assessed for self-care, self-control, health management and medical treatment. A moderate to severe level of disorganization and emotional distress was observed in 38% and impaired subjective well-being in 29% of patients defined as being in symptomatic remission. Discussion: The results confirm a close association between symptomatic remission and functional outcome. However, deficits in different areas of functioning, symptoms and well-being underline the need for combined outcome criteria for patients with schizophrenia.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalEuropean Psychiatry
Volume27
Issue number6
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

Keywords

  • Functional outcome
  • Recovery
  • Remission
  • Schizophrenia
  • Subjective well-being

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