Removal of cytomegalovirus DNA from donor blood by filtration

Karen L. Smith; Trevor Cobain; Robert A. Dunstan

doi:10.1111/j.1365-2141.1993.tb04703.x

Removal of cytomegalovirus DNA from donor blood by filtration

Karen L. Smith^*, Trevor Cobain, Robert A. Dunstan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Summary. Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymer‐ ase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre‐ and post‐filtration samples by PCR with ethidium bromide staining has shown that filtration was successful in removing CMV DNA from all samples. This is evidence that leucocyte filtration of red cell concentrates may greatly decrease the risk of CMV disease following transfusion to susceptible patients.

Original language	English
Pages (from-to)	640-642
Number of pages	3
Journal	British Journal of Haematology
Volume	83
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.1993.tb04703.x
Publication status	Published - 1993
Externally published	Yes

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10.1111/j.1365-2141.1993.tb04703.x

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title = "Removal of cytomegalovirus DNA from donor blood by filtration",

abstract = "Summary. Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymer‐ ase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre‐ and post‐filtration samples by PCR with ethidium bromide staining has shown that filtration was successful in removing CMV DNA from all samples. This is evidence that leucocyte filtration of red cell concentrates may greatly decrease the risk of CMV disease following transfusion to susceptible patients.",

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AU - Cobain, Trevor

AU - Dunstan, Robert A.

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N2 - Summary. Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymer‐ ase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre‐ and post‐filtration samples by PCR with ethidium bromide staining has shown that filtration was successful in removing CMV DNA from all samples. This is evidence that leucocyte filtration of red cell concentrates may greatly decrease the risk of CMV disease following transfusion to susceptible patients.

AB - Summary. Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymer‐ ase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre‐ and post‐filtration samples by PCR with ethidium bromide staining has shown that filtration was successful in removing CMV DNA from all samples. This is evidence that leucocyte filtration of red cell concentrates may greatly decrease the risk of CMV disease following transfusion to susceptible patients.

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Removal of cytomegalovirus DNA from donor blood by filtration

Abstract

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