Removal of cytomegalovirus DNA from donor blood by filtration

Karen L. Smith*, Trevor Cobain, Robert A. Dunstan

*Corresponding author for this work

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Summary. Blood from five donors, previously shown to be positive for cytomegalovirus (CMV) DNA following polymer‐ ase chain reaction (PCR) amplification, was filtered through commercially available leucocyte filters. Analysis of pre‐ and post‐filtration samples by PCR with ethidium bromide staining has shown that filtration was successful in removing CMV DNA from all samples. This is evidence that leucocyte filtration of red cell concentrates may greatly decrease the risk of CMV disease following transfusion to susceptible patients.

Original languageEnglish
Pages (from-to)640-642
Number of pages3
JournalBritish Journal of Haematology
Volume83
Issue number4
DOIs
Publication statusPublished - 1993
Externally publishedYes

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