@article{263768649487433aa415db9601eb8772,
title = "RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus",
abstract = "Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice. Currently, there are few effective pharmacological treatments for Lewy body dementia (which includes both dementia with Lewy bodies and Parkinson{\textquoteright}s disease dementia) apart from cholinesterase inhibitors. We reviewed several promising compounds that might potentially be disease-modifying agents for Lewy body dementia and then undertook an International Delphi consensus study to prioritise compounds. We identified ambroxol as the top ranked agent for repurposing and identified a further six agents from the classes of tyrosine kinase inhibitors, GLP-1 receptor agonists, and angiotensin receptor blockers that were rated by the majority of our expert panel as justifying a clinical trial. It would now be timely to take forward all these compounds to Phase II or III clinical trials in Lewy body dementia.",
author = "O{\textquoteright}Brien, {John T.} and Leonidas Chouliaras and Janet Sultana and John-Paul Taylor and Clive Ballard and {on behalf of the RENEWAL Study Group} and Dag Aarsland and Frederic Blanc and Bradley Boeve and Brooks, {David J.} and Chaudhuri, {K. Ray} and Jeffrey Cummings and Feldman, {Howard H.} and Leon Flicker and Galvin, {James E.} and Grosset, {Donald G.} and Manabu Ikeda and Susan Kohlhaas and Brian Lawlor and Lemstra, {Afina W.} and Iracema Leroi and Elisabet Londos and Leverenz, {James B.} and Simon Lewis and Ian McKeith and Roger Mills and Richard Oakley and Jill Richardson and Marwan Sabbagh and John Skidmore and Per Svennigsson and Pietro Tiraboschi and Daniel Weintraub and Zuzana Walker and Rosie Watson and Weil, {Rimona S.} and Williams-Gray, {Caroline H.} and Alison Yarnall",
note = "Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",
year = "2022",
month = nov,
day = "11",
doi = "10.1186/s13195-022-01103-7",
language = "English",
volume = "14",
pages = "1--17",
journal = "Alzheimer's Research and Therapy",
issn = "1758-9193",
publisher = "Springer, Springer Nature",
number = "1",
}