Repeated cocaine administration into the rat ventral tegmental area produces behavioral sensitization to a systemic cocaine challenge

Jennifer L. Cornish*, Peter W. Kalivas

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The aim of the present study was to investigate the capacity of repeated administration of cocaine (5 nmol/side) or the selective dopamine re-uptake inhibitor GBR 12909 (15 nmol/side) into the ventral tegmental area (VTA) to initiate behavioral sensitization to systemically administered cocaine (15 mg/kg, intraperitoneally). Following 1 week of withdrawal from intra-VTA treatment, cocaine or GBR 12909 pretreated animals displayed sensitized locomotor and rearing behavior to acute systemic cocaine administration. These data support the possibility that increased dopamine transmission in the VTA is involved in the cellular events that determine the initiation of behavioral sensitization to cocaine.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalBehavioural Brain Research
Volume126
Issue number1-2
DOIs
Publication statusPublished - 29 Nov 2001
Externally publishedYes

Keywords

  • Behavioral sensitization
  • Cocaine
  • GBR 12909
  • Locomotor activity
  • Psychostimulant
  • Rat
  • Ventral tegmental area

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