In six experiments, we investigated the influence of featural differences between targets and distractors on the detection and identification of dissimilar and repeated targets in conditions that typically produce an attentional blink and repetition blindness (when a target is repeated). Rapid serial visual presentation streams were presented that contained letter targets and distractors that were either letters or digits. The targets and the distractors were either the same color or a different color and were presented either in the same font or in a different font. Dual-target performance on nonrepeat trials was strongly enhanced when the targets were colored. In addition, when subjects used either the color or the font cues to select the targets, there was benefit of repetition on dual-target report, instead of repetition blindness. The results suggest that featural differences between targets and distractors play an important role in registering stimuli as distinct objects.