Research criteria for the diagnosis of prodromal dementia with Lewy bodies

Ian G. McKeith; Tanis J. Ferman; Alan J. Thomas; Frédéric Blanc; Bradley F. Boeve; Hiroshige Fujishiro; Kejal Kantarci; Cristina Muscio; John T. O'Brien; Ronald B. Postuma; Dag Aarsland; Clive Ballard; Laura Bonanni; Paul Donaghy; Murat Emre; James E. Galvin; Douglas Galasko; Jennifer G. Goldman; Stephen N. Gomperts; Lawrence S. Honig; Manabu Ikeda; James B. Leverenz; Simon J. G. Lewis; Karen S. Marder; Mario Masellis; David P. Salmon; John-Paul Taylor; Debby W. Tsuang; Zuzana Walker; Pietro Tiraboschi; prodromal DLB Diagnostic Study Group

doi:10.1212/WNL.0000000000009323

Research criteria for the diagnosis of prodromal dementia with Lewy bodies

Ian G. McKeith, Tanis J. Ferman, Alan J. Thomas, Frédéric Blanc, Bradley F. Boeve, Hiroshige Fujishiro, Kejal Kantarci, Cristina Muscio, John T. O'Brien, Ronald B. Postuma, Dag Aarsland, Clive Ballard, Laura Bonanni, Paul Donaghy, Murat Emre, James E. Galvin, Douglas Galasko, Jennifer G. Goldman, Stephen N. Gomperts, Lawrence S. HonigManabu Ikeda, James B. Leverenz, Simon J. G. Lewis, Karen S. Marder, Mario Masellis, David P. Salmon, John-Paul Taylor, Debby W. Tsuang, Zuzana Walker, Pietro Tiraboschi, prodromal DLB Diagnostic Study Group

Research output: Contribution to journal › Review article › peer-review

493 Citations (Scopus)

17 Downloads (Pure)

Abstract

The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.

Original language	English
Pages (from-to)	743-755
Number of pages	13
Journal	Neurology
Volume	94
Issue number	17
DOIs	https://doi.org/10.1212/WNL.0000000000009323
Publication status	Published - 28 Apr 2020
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Humans
Lewy Body Disease/diagnosis
Prodromal Symptoms

Access to Document

10.1212/WNL.0000000000009323Licence: CC BY-NC-ND

Publisher version (open access)Final published version, 341 KBLicence: CC BY-NC-ND

Cite this

McKeith, I. G., Ferman, T. J., Thomas, A. J., Blanc, F., Boeve, B. F., Fujishiro, H., Kantarci, K., Muscio, C., O'Brien, J. T., Postuma, R. B., Aarsland, D., Ballard, C., Bonanni, L., Donaghy, P., Emre, M., Galvin, J. E., Galasko, D., Goldman, J. G., Gomperts, S. N., ... prodromal DLB Diagnostic Study Group (2020). Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology, 94(17), 743-755. https://doi.org/10.1212/WNL.0000000000009323

@article{06b5370ed1184fe3bced64fa8ea6db7b,

title = "Research criteria for the diagnosis of prodromal dementia with Lewy bodies",

abstract = "The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.",

keywords = "Humans, Lewy Body Disease/diagnosis, Prodromal Symptoms",

author = "McKeith, {Ian G.} and Ferman, {Tanis J.} and Thomas, {Alan J.} and Fr{\'e}d{\'e}ric Blanc and Boeve, {Bradley F.} and Hiroshige Fujishiro and Kejal Kantarci and Cristina Muscio and O'Brien, {John T.} and Postuma, {Ronald B.} and Dag Aarsland and Clive Ballard and Laura Bonanni and Paul Donaghy and Murat Emre and Galvin, {James E.} and Douglas Galasko and Goldman, {Jennifer G.} and Gomperts, {Stephen N.} and Honig, {Lawrence S.} and Manabu Ikeda and Leverenz, {James B.} and Lewis, {Simon J. G.} and Marder, {Karen S.} and Mario Masellis and Salmon, {David P.} and John-Paul Taylor and Tsuang, {Debby W.} and Zuzana Walker and Pietro Tiraboschi and {prodromal DLB Diagnostic Study Group}",

note = "Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2020",

month = apr,

day = "28",

doi = "10.1212/WNL.0000000000009323",

language = "English",

volume = "94",

pages = "743--755",

journal = "Neurology",

issn = "0028-3878",

publisher = "AAN Enterprises",

number = "17",

}

McKeith, IG, Ferman, TJ, Thomas, AJ, Blanc, F, Boeve, BF, Fujishiro, H, Kantarci, K, Muscio, C, O'Brien, JT, Postuma, RB, Aarsland, D, Ballard, C, Bonanni, L, Donaghy, P, Emre, M, Galvin, JE, Galasko, D, Goldman, JG, Gomperts, SN, Honig, LS, Ikeda, M, Leverenz, JB, Lewis, SJG, Marder, KS, Masellis, M, Salmon, DP, Taylor, J-P, Tsuang, DW, Walker, Z, Tiraboschi, P & prodromal DLB Diagnostic Study Group 2020, 'Research criteria for the diagnosis of prodromal dementia with Lewy bodies', Neurology, vol. 94, no. 17, pp. 743-755. https://doi.org/10.1212/WNL.0000000000009323

TY - JOUR

T1 - Research criteria for the diagnosis of prodromal dementia with Lewy bodies

AU - McKeith, Ian G.

AU - Ferman, Tanis J.

AU - Thomas, Alan J.

AU - Blanc, Frédéric

AU - Boeve, Bradley F.

AU - Fujishiro, Hiroshige

AU - Kantarci, Kejal

AU - Muscio, Cristina

AU - O'Brien, John T.

AU - Postuma, Ronald B.

AU - Aarsland, Dag

AU - Ballard, Clive

AU - Bonanni, Laura

AU - Donaghy, Paul

AU - Emre, Murat

AU - Galvin, James E.

AU - Galasko, Douglas

AU - Goldman, Jennifer G.

AU - Gomperts, Stephen N.

AU - Honig, Lawrence S.

AU - Ikeda, Manabu

AU - Leverenz, James B.

AU - Lewis, Simon J. G.

AU - Marder, Karen S.

AU - Masellis, Mario

AU - Salmon, David P.

AU - Taylor, John-Paul

AU - Tsuang, Debby W.

AU - Walker, Zuzana

AU - Tiraboschi, Pietro

AU - prodromal DLB Diagnostic Study Group

N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/4/28

Y1 - 2020/4/28

N2 - The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.

AB - The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.

KW - Humans

KW - Lewy Body Disease/diagnosis

KW - Prodromal Symptoms

UR - http://www.scopus.com/inward/record.url?scp=85084763016&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000009323

DO - 10.1212/WNL.0000000000009323

M3 - Review article

C2 - 32241955

SN - 0028-3878

VL - 94

SP - 743

EP - 755

JO - Neurology

JF - Neurology

IS - 17

ER -

Research criteria for the diagnosis of prodromal dementia with Lewy bodies

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this