TY - JOUR
T1 - Resection of colorectal liver metastases and extra-hepatic disease
T2 - a systematic review and proportional meta-analysis of survival outcomes
AU - Hadden, William J.
AU - de Reuver, Philip R.
AU - Brown, Kai
AU - Mittal, Anubhav
AU - Samra, Jaswinder S.
AU - Hugh, Thomas J.
PY - 2016
Y1 - 2016
N2 - Background Colorectal cancer (CRC) accounts for 9.7% of all cancers with 1.4 million new cases diagnosed each year. 19–31% of CRC patients develop colorectal liver metastases (CRLM), and 23–38% develop extra-hepatic disease (EHD). The aim of this systematic review was to determine overall survival (OS) in patients resected for CRLM and known EHD. Methods A systematic review was undertaken to identify studies reporting OS after resection for CRLM in the presence of EHD. Proportional meta-analyses and relative risk of death before five years were assessed between patient groups. Results A total of 15,144 patients with CRLM (2308 with EHD) from 52 studies were included. Three and 5-year OS were 58% and 26% for lung, 37% and 17% for peritoneum, and 35% and 15% for lymph nodes, respectively. The combined relative risk of death by five years was 1.49 (95% CI = 1.34–1.66) for lung, 1.59 (95% CI = 1.16–2.17) for peritoneal and 1.70 (95% CI = 1.57–1.84) for lymph node EHD, in favour of resection in the absence of EHD. Conclusion This review supports attempts at R0 resection in selected patients and rejects the notion that EHD is an absolute contraindication to resection.
AB - Background Colorectal cancer (CRC) accounts for 9.7% of all cancers with 1.4 million new cases diagnosed each year. 19–31% of CRC patients develop colorectal liver metastases (CRLM), and 23–38% develop extra-hepatic disease (EHD). The aim of this systematic review was to determine overall survival (OS) in patients resected for CRLM and known EHD. Methods A systematic review was undertaken to identify studies reporting OS after resection for CRLM in the presence of EHD. Proportional meta-analyses and relative risk of death before five years were assessed between patient groups. Results A total of 15,144 patients with CRLM (2308 with EHD) from 52 studies were included. Three and 5-year OS were 58% and 26% for lung, 37% and 17% for peritoneum, and 35% and 15% for lymph nodes, respectively. The combined relative risk of death by five years was 1.49 (95% CI = 1.34–1.66) for lung, 1.59 (95% CI = 1.16–2.17) for peritoneal and 1.70 (95% CI = 1.57–1.84) for lymph node EHD, in favour of resection in the absence of EHD. Conclusion This review supports attempts at R0 resection in selected patients and rejects the notion that EHD is an absolute contraindication to resection.
UR - http://www.scopus.com/inward/record.url?scp=84976415894&partnerID=8YFLogxK
U2 - 10.1016/j.hpb.2015.12.004
DO - 10.1016/j.hpb.2015.12.004
M3 - Review article
C2 - 27017160
AN - SCOPUS:84976415894
SN - 1365-182X
VL - 18
SP - 209
EP - 220
JO - HPB
JF - HPB
IS - 3
ER -