Resveratrol solid lipid microparticles as dry powder formulation for nasal delivery, characterization and in vitro deposition study

Isabella Martignoni, Valentina Trotta, Wing-Hin Lee, Ching-Yee Loo, Michele Pozzoli, Paul M. Young, Santo Scalia*, Daniela Traini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical characteristics of the SLMs loaded with resveratrol were evaluated in terms of morphology, size, thermal behaviour and moisture sorption. The SLMs appeared as aggregates larger than 20 μm. In vitro nasal deposition was evaluated using a USP specification Apparatus E 7-stage cascade impactor equipped with a standard or a modified nasal deposition apparatus. More than 95% of resveratrol was recovered onto the nasal deposition chamber and stage 1 of impactor, suggesting that the SLMs mostly deposited in the nasal cavity. Additionally, the SLMs were not toxic on RPMI 2650 nasal cell line up to a concentration of approximately 40 μM of resveratrol.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalJournal of Microencapsulation
Volume33
Issue number8
DOIs
Publication statusPublished - 16 Nov 2016
Externally publishedYes

Keywords

  • chitosan
  • in vitro models
  • Nasal drug delivery
  • solid lipid microparticles

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