Reversible energy-transfer switching on a DNA scaffold

Magnus Bälter, Martin Hammarson, Patricia Remón, Shiming Li, Nittaya Gale, Tom Brown, Joakim Andréasson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)
5 Downloads (Pure)


We show that FRET between Pacific Blue (PB) and Alexa488 (A488) covalently attached to a DNA scaffold can be reversibly controlled by photochromic switching of a spiropyran derivative. With the spiropyran in the closed spiro isomeric form, FRET occurs freely between PB and A488. UV-induced isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of the PB excited state. The process is reversed by exposure to visible light, triggering the isomerization to the spiro isomer.

Original languageEnglish
Pages (from-to)2444-2447
Number of pages4
JournalJournal of the American Chemical Society
Issue number7
Publication statusPublished - 25 Feb 2015
Externally publishedYes

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