Review and recommendations for the component tests in the liver function test profile

Tony Badrick*, Peter Turner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Pathology laboratories group some tests that they perform on their high throughput biochemistry analysers into profiles of tests that are associated with different organs (e.g. liver function tests—LFT). The components of these profiles are historic and often vary between different laboratories. This can lead to confusion and begs the question of what should be in a particular profile. In community medicine profiles may be used as screening tests but some of the components of the profiles may have low sensitivity and specificity and may produce both false positives and negatives. The LFT may include components which are poor liver function tests but are sensitive to fatty liver and hence elevations may cause unnecessary concern. Harmonisation of clinical chemistry reference intervals and units is occurring now so it is time to consider a similar process for components of a profile. A proposed list of analytes to be performed in the LFT profile is given.

Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalIndian Journal of Clinical Biochemistry
Issue number1
Publication statusPublished - 1 Mar 2016
Externally publishedYes


  • clinical chemistry profiles
  • liver function test
  • harmonisation


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