Rhodiola rosea L. and Alzheimer's disease: from farm to pharmacy

Seyed Fazel Nabavi, Nady Braidy*, Ilkay Erdogan Orhan, Arash Badiee, Maria Daglia, Seyed Mohammad Nabavi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

63 Citations (Scopus)


Rhodiola rosea L. (roseroot) is a common member of the family Crassulaceae, known as one of the most important popular medicinal plants in the northern region of Europe. The roots of R. rosea possess a wide range of pharmacological activities such as antioxidant, antiinflammatory, anticancer, cardioprotective, and neuroprotective effects that are because of the presence of different phytochemicals such as phenols and flavonoids. In addition, the presence of salidroside, rosavins, and p-tyrosol are responsible for its beneficial effects for the treatment of on depression, fatigue, and cognitive dysfunction. A plethora of studies report that R. rosea has potent neuroprotective effects through the suppression of oxidative stress, neuroinflammation, and excitotoxicity in brain tissues and antagonism of oncogenic p21-activated kinase. However, to our knowledge, no review articles have been published addressing the neuroprotective effects of R. rosea. Therefore, the present article aims at critically reviewing the available literature on the beneficial effects of R. rosea on as a therapeutic strategy for the treatment of Alzheimer's disease and other neurodegenerative diseases where oxidative stress plays a major role in disease development and progression. We also discuss the cultivation, phytochemistry, clinical impacts, and adverse effects of R. rosea to provide a broader insight on the therapeutic potential for this plant.

Original languageEnglish
Pages (from-to)532-539
Number of pages8
JournalPhytotherapy Research
Issue number4
Publication statusPublished - 1 Apr 2016
Externally publishedYes


  • Alzheimer Disease
  • Clinical Trials as Topic
  • Cognition Disorders
  • Disaccharides
  • Glucosides
  • Humans
  • Neuroprotective Agents
  • Oxidative Stress
  • Phenols
  • Phenylethyl Alcohol
  • Plant Extracts
  • Plant Roots
  • Plants, Medicinal
  • Rhodiola
  • p21-Activated Kinases
  • Journal Article
  • Review


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