The synthesis and resolution of two chiral carbocyclic cleft molecules containing carbonyl groups on the periphery of the cavity are reported. These compounds are reminiscent of Troger's base but contain a smaller cleft and additional carbonyl (or alcohol) groups. X-ray crystal structures of the dibromo and dimethyl derivatives show that the dihedral angle between the two aromatic rings is 79°and 85°respectively. The dibromo derivative provides entry into new supramolecular hosts, via introduction of additional recognition groups into the cleft molecules.
|Number of pages||4|
|Publication status||Published - 24 Dec 1998|