Rising prevalence of human papillomavirus-related oropharyngeal cancer in Australia over the last 2 decades

Angela Hong*, C. Soon Lee, Deanna Jones, Anne Sophie Veillard, Mei Zhang, Xiaoying Zhang, Robert Smee, June Corry, Sandro Porceddu, Christopher Milross, Michael Elliott, Jonathan Clark, Barbara Rose

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: This study provides Australian data on the characteristics of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) over the last 2 decades. 

Methods: The HPV status of 515 patients with oropharyngeal SCC diagnosed between 1987 and 2010 was determined by HPV E6-targeted multiplex real time polymerase chain reaction assay (PCR) and p16 immunohistochemistry. 

Results: The HPV positivity rate increased from 20.2% (1987-1995) to 63.5% (2006-2010). Among HPV-positive oropharyngeal SCC over the study period, the median age increased from 55.4 years to 59.8 years (p = .004) and there was a trend of an increasing proportion of never smokers (19.2% to 34.0%). The use of radiation therapy (RT) in patients with HPV-positive oropharyngeal cancer increased from 26.9% to 68.1% (p = .007) and we also observed a trend of improved outcomes. 

Conclusion: Our data show a rising prevalence of HPV-positive oropharyngeal SCC in Australia over the last 2 decades. These patients with HPV-positive oropharyngeal SCC are now presenting at an older age and about one third have never smoked.

Original languageEnglish
Pages (from-to)743-750
Number of pages8
JournalHead and Neck
Volume38
Issue number5
DOIs
Publication statusPublished - May 2016
Externally publishedYes

Keywords

  • human papillomavirus (HPV)
  • oropharyngeal cancer
  • head and neck cancer

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    Hong, A., Lee, C. S., Jones, D., Veillard, A. S., Zhang, M., Zhang, X., ... Rose, B. (2016). Rising prevalence of human papillomavirus-related oropharyngeal cancer in Australia over the last 2 decades. Head and Neck, 38(5), 743-750. https://doi.org/10.1002/hed.23942