RNA binding proteins in the miRNA pathway

Patrick Connerty; Alireza Ahadi; Gyorgy Hutvagner

doi:10.3390/ijms17010031

RNA binding proteins in the miRNA pathway

Patrick Connerty, Alireza Ahadi, Gyorgy Hutvagner^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

67 Citations (Scopus)

34 Downloads (Pure)

Abstract

microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.

Original language	English
Article number	31
Number of pages	16
Journal	International Journal of Molecular Sciences
Volume	17
Issue number	1
DOIs	https://doi.org/10.3390/ijms17010031
Publication status	Published - 2016
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

miRNA
RNA binding protein
Drosha
Dicer
Argonaute
cross-linking and immonoprecipitation (CLIP)

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10.3390/ijms17010031Licence: CC BY

Publisher version (open access)Final published version, 853 KBLicence: CC BY

Cite this

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AU - Connerty, Patrick

AU - Ahadi, Alireza

AU - Hutvagner, Gyorgy

N1 - Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2016

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N2 - microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.

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KW - RNA binding protein

KW - Drosha

KW - Dicer

KW - Argonaute

KW - cross-linking and immonoprecipitation (CLIP)

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RNA binding proteins in the miRNA pathway

Abstract

Bibliographical note

Keywords

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