Role of increased aortic stiffness in the pathogenesis of heart failure

J. Cheriyan, Ian B. Wilkinson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Aortic stiffness is an independent predictor of cardiovascular mortality in a variety of patient groups including hypertensives and other unselected patients. Despite a sound pathophysiologic basis, termed the ventricular-vascular coupling mechanism, the relationship between aortic stiffness and heart failure has been less well studied. This review summarizes some important trials of aortic stiffness in cardiovascular disease risk prediction and progression to heart failure. Emerging targets for therapeutics and areas requiring more research are also discussed.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalCurrent Heart Failure Reports
Issue number3
Publication statusPublished - Sep 2007
Externally publishedYes


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