Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis

I. T. Paulsen*, L. Banerjei, G. S A Hyers, K. E. Nelson, R. Seshadri, T. D. Read, D. E. Fouts, J. A. Eisen, S. R. Gill, J. F. Heidelberg, H. Tettelin, R. J. Dodson, L. Umayam, L. Brinkac, M. Beanan, S. Daugherty, R. T. DeBoy, S. Durkin, J. Kolonay, R. Madupu & 12 others W. Nelson, J. Vamathevan, B. Tran, J. Upton, T. Hansen, J. Shetty, H. Khouri, T. Utterback, D. Radune, K. A. Ketchum, B. A. Dougherty, C. M. Fraser

*Corresponding author for this work

Research output: Contribution to journalArticle

626 Citations (Scopus)

Abstract

The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.

Original languageEnglish
Pages (from-to)2071-2074
Number of pages4
JournalScience
Volume299
Issue number5615
DOIs
Publication statusPublished - 28 Mar 2003
Externally publishedYes

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    Paulsen, I. T., Banerjei, L., Hyers, G. S. A., Nelson, K. E., Seshadri, R., Read, T. D., ... Fraser, C. M. (2003). Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science, 299(5615), 2071-2074. https://doi.org/10.1126/science.1080613