Role of the microenvironment in chronic pancreatitis and pancreatic cancer

Andreia V. Pinho, Minoti V. Apte, Jeremy S. Wilson, Ilse Rooman

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Chronic pancreatitis, an inflammatory disease of the exocrine pancreas, has been reported to be a major risk factor for the development of pancreatic ductal adenocarcinoma. Evidence from pre-clinical mouse models has shown that both diseases share a common origin in the digestive enzyme-producing acinar cells, through acinar to ductal metaplasia. Moreover, both diseases are characterised by the presence of an abundant stroma, the components of which include activated pancreatic stellate cells and immune cell infiltrates, which signal to epithelial cells through the production of cytokines and chemokines. In this review we explore the links between chronic pancreatitis and pancreatic ductal adenocarcinoma, with particular reference to the role of the microenvironment in both diseases. A better understanding of the nature of the epithelial and stromal changes, as well as their interactions, has led to trialling novel therapeutic strategies for the prevention and/or treatment of pancreatic cancer.

LanguageEnglish
Pages11-15
Number of pages5
JournalCancer Forum
Volume40
Issue number1
Publication statusPublished - 1 Mar 2016
Externally publishedYes

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Chronic Pancreatitis
Pancreatic Neoplasms
Adenocarcinoma
Pancreatic Stellate Cells
Exocrine Pancreas
Acinar Cells
Metaplasia
Chemokines
Epithelial Cells
Cytokines
Enzymes
Therapeutics

Cite this

Pinho, A. V., Apte, M. V., Wilson, J. S., & Rooman, I. (2016). Role of the microenvironment in chronic pancreatitis and pancreatic cancer. Cancer Forum, 40(1), 11-15.
Pinho, Andreia V. ; Apte, Minoti V. ; Wilson, Jeremy S. ; Rooman, Ilse. / Role of the microenvironment in chronic pancreatitis and pancreatic cancer. In: Cancer Forum. 2016 ; Vol. 40, No. 1. pp. 11-15.
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Pinho, AV, Apte, MV, Wilson, JS & Rooman, I 2016, 'Role of the microenvironment in chronic pancreatitis and pancreatic cancer', Cancer Forum, vol. 40, no. 1, pp. 11-15.

Role of the microenvironment in chronic pancreatitis and pancreatic cancer. / Pinho, Andreia V.; Apte, Minoti V.; Wilson, Jeremy S.; Rooman, Ilse.

In: Cancer Forum, Vol. 40, No. 1, 01.03.2016, p. 11-15.

Research output: Contribution to journalReview articleResearchpeer-review

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AB - Chronic pancreatitis, an inflammatory disease of the exocrine pancreas, has been reported to be a major risk factor for the development of pancreatic ductal adenocarcinoma. Evidence from pre-clinical mouse models has shown that both diseases share a common origin in the digestive enzyme-producing acinar cells, through acinar to ductal metaplasia. Moreover, both diseases are characterised by the presence of an abundant stroma, the components of which include activated pancreatic stellate cells and immune cell infiltrates, which signal to epithelial cells through the production of cytokines and chemokines. In this review we explore the links between chronic pancreatitis and pancreatic ductal adenocarcinoma, with particular reference to the role of the microenvironment in both diseases. A better understanding of the nature of the epithelial and stromal changes, as well as their interactions, has led to trialling novel therapeutic strategies for the prevention and/or treatment of pancreatic cancer.

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