Role of the protein tau in Alzheimer's disease

Jürgen Götz; Lars M. Ittner; Della C. David

doi:10.1016/j.ddmec.2005.11.008

Role of the protein tau in Alzheimer's disease

Jürgen Götz^*, Lars M. Ittner, Della C. David

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Alzheimer's disease is the most prevalent neurodegenerative disorder. The histopathological profile includes β-amyloid-containing plaques and tau-containing neurofibrillary tangles. These hallmark lesions have been reproduced in brains of transgenic animal models. Here, we discuss recent developments to assess specifically the role of tau in neurodegeneration using transgenic mice. Insight gained from these mice might be useful in identifying targets and in developing treatment strategies.

Original language	English
Pages (from-to)	395-400
Number of pages	6
Journal	Drug Discovery Today: Disease Mechanisms
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmec.2005.11.008
Publication status	Published - 1 Dec 2005
Externally published	Yes

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10.1016/j.ddmec.2005.11.008

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title = "Role of the protein tau in Alzheimer's disease",

abstract = "Alzheimer's disease is the most prevalent neurodegenerative disorder. The histopathological profile includes β-amyloid-containing plaques and tau-containing neurofibrillary tangles. These hallmark lesions have been reproduced in brains of transgenic animal models. Here, we discuss recent developments to assess specifically the role of tau in neurodegeneration using transgenic mice. Insight gained from these mice might be useful in identifying targets and in developing treatment strategies.",

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AU - Götz, Jürgen

AU - Ittner, Lars M.

AU - David, Della C.

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N2 - Alzheimer's disease is the most prevalent neurodegenerative disorder. The histopathological profile includes β-amyloid-containing plaques and tau-containing neurofibrillary tangles. These hallmark lesions have been reproduced in brains of transgenic animal models. Here, we discuss recent developments to assess specifically the role of tau in neurodegeneration using transgenic mice. Insight gained from these mice might be useful in identifying targets and in developing treatment strategies.

AB - Alzheimer's disease is the most prevalent neurodegenerative disorder. The histopathological profile includes β-amyloid-containing plaques and tau-containing neurofibrillary tangles. These hallmark lesions have been reproduced in brains of transgenic animal models. Here, we discuss recent developments to assess specifically the role of tau in neurodegeneration using transgenic mice. Insight gained from these mice might be useful in identifying targets and in developing treatment strategies.

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DO - 10.1016/j.ddmec.2005.11.008

M3 - Review article

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VL - 2

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JO - Drug Discovery Today: Disease Mechanisms

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Role of the protein tau in Alzheimer's disease

Abstract

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