Scaling deterministic lateral displacement arrays for high throughput and dilution-free enrichment of leukocytes

David W. Inglis, Megan Lord, Robert E. Nordon

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

A disposable device for fractionation of blood into its components that is simple to operate and provides throughput of greater than 1 mL min -1 is highly sought after in medical diagnostics and therapies. This paper describes a device with parallel deterministic lateral displacement devices for enrichment of leukocytes from blood. We show capture of 98% and approximately ten-fold enrichment of leukocytes in whole blood. We demonstrate scaling up through the integration of six parallel devices to achieve a flow rate of 115 νL of undiluted blood per minute per atmosphere of applied pressure.

Original languageEnglish
Article number054024
Pages (from-to)1-8
Number of pages8
JournalJournal of Micromechanics and Microengineering
Volume21
Issue number5
DOIs
Publication statusPublished - May 2011

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