TY - JOUR
T1 - Scar tissue classification using nonlinear optical microscopy and discriminant analysis
AU - Kelf, Timothy Andrew
AU - Gosnell, Martin
AU - Sandnes, Bjornar
AU - Guller, Anna E.
AU - Shekhter, Anatoly B.
AU - Zvyagin, Andrei V.
PY - 2012/2
Y1 - 2012/2
N2 - This paper addresses the scar tissue maturation process that occurs stepwise, and calls for reliable classification. The structure of collagen imaged by nonlinear optical microscopy (NLOM) in post-burn hypertrophic and mature scar, as well as in normal skin, appeared to distinguish these maturation steps. However, it was a discrimination analysis, demonstrated here, that automated and quantified the scar tissue maturation process. The achieved scar classification accuracy was as high as 96%. The combination of NLOM and discrimination analysis is believed to be instrumental in gaining insight into the scar formation, for express diagnosis of scar and surgery planning.
AB - This paper addresses the scar tissue maturation process that occurs stepwise, and calls for reliable classification. The structure of collagen imaged by nonlinear optical microscopy (NLOM) in post-burn hypertrophic and mature scar, as well as in normal skin, appeared to distinguish these maturation steps. However, it was a discrimination analysis, demonstrated here, that automated and quantified the scar tissue maturation process. The achieved scar classification accuracy was as high as 96%. The combination of NLOM and discrimination analysis is believed to be instrumental in gaining insight into the scar formation, for express diagnosis of scar and surgery planning.
UR - http://www.scopus.com/inward/record.url?scp=84856060961&partnerID=8YFLogxK
U2 - 10.1002/jbio.201100075
DO - 10.1002/jbio.201100075
M3 - Article
C2 - 22105878
AN - SCOPUS:84856060961
VL - 5
SP - 159
EP - 167
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 2
ER -