SCL gene in human tumors

S. Rockman, C. G. Begley*, G. Kannourakis, G. J. Mann, A. N. Dobrovic, R. F. Kefford, K. McGrath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalLeukemia
Volume6
Issue number7
Publication statusPublished - 1992
Externally publishedYes

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