SCL gene in human tumors

S. Rockman; C. G. Begley; G. Kannourakis; G. J. Mann; A. N. Dobrovic; R. F. Kefford; K. McGrath

SCL gene in human tumors

S. Rockman, C. G. Begley^*, G. Kannourakis, G. J. Mann, A. N. Dobrovic, R. F. Kefford, K. McGrath

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.

Original language	English
Pages (from-to)	623-625
Number of pages	3
Journal	Leukemia
Volume	6
Issue number	7
Publication status	Published - 1992
Externally published	Yes

Cite this

@article{5499ca06b597497db825cc33a8bb4d33,

title = "SCL gene in human tumors",

abstract = "The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.",

author = "S. Rockman and Begley, {C. G.} and G. Kannourakis and Mann, {G. J.} and Dobrovic, {A. N.} and Kefford, {R. F.} and K. McGrath",

year = "1992",

language = "English",

volume = "6",

pages = "623--625",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Springer, Springer Nature",

number = "7",

}

TY - JOUR

T1 - SCL gene in human tumors

AU - Rockman, S.

AU - Begley, C. G.

AU - Kannourakis, G.

AU - Mann, G. J.

AU - Dobrovic, A. N.

AU - Kefford, R. F.

AU - McGrath, K.

PY - 1992

Y1 - 1992

N2 - The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.

AB - The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.

UR - http://www.scopus.com/inward/record.url?scp=0026695994&partnerID=8YFLogxK

M3 - Article

C2 - 1625484

AN - SCOPUS:0026695994

SN - 0887-6924

VL - 6

SP - 623

EP - 625

JO - Leukemia

JF - Leukemia

IS - 7

ER -

SCL gene in human tumors

Abstract

Other files and links

Fingerprint

Cite this