SCORPION2: a database for structure-function analysis of scorpion toxins

Paul T J Tan; Anitha Veeramani; Kellathur N. Srinivasan; Shoba Ranganathan; Vladimir Brusic

doi:10.1016/j.toxicon.2005.12.001

SCORPION2: a database for structure-function analysis of scorpion toxins

Paul T J Tan^*, Anitha Veeramani, Kellathur N. Srinivasan, Shoba Ranganathan, Vladimir Brusic

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Scorpion toxins are important experimental tools for characterization of vast array of ion channels and serve as scaffolds for drug design. General public database entries contain limited annotation whereby rich structure-function information from mutation studies is typically not available. SCORPION2 contains more than 800 records of native and mutant toxin sequences enriched with binding affinity and toxicity information, 624 three-dimensional structures and some 500 references. SCORPION2 has a set of search and prediction tools that allow users to extract and perform specific queries: text searches of scorpion toxin records, sequence similarity search, extraction of sequences, visualization of scorpion toxin structures, analysis of toxic activity, and functional annotation of previously uncharacterized scorpion toxins. The SCORPION2 database is available at http://sdmc.i2r.a-star.edu.sg/scorpion/.

Original language	English
Pages (from-to)	356-363
Number of pages	8
Journal	Toxicon
Volume	47
Issue number	3
DOIs	https://doi.org/10.1016/j.toxicon.2005.12.001
Publication status	Published - 1 Mar 2006

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abstract = "Scorpion toxins are important experimental tools for characterization of vast array of ion channels and serve as scaffolds for drug design. General public database entries contain limited annotation whereby rich structure-function information from mutation studies is typically not available. SCORPION2 contains more than 800 records of native and mutant toxin sequences enriched with binding affinity and toxicity information, 624 three-dimensional structures and some 500 references. SCORPION2 has a set of search and prediction tools that allow users to extract and perform specific queries: text searches of scorpion toxin records, sequence similarity search, extraction of sequences, visualization of scorpion toxin structures, analysis of toxic activity, and functional annotation of previously uncharacterized scorpion toxins. The SCORPION2 database is available at http://sdmc.i2r.a-star.edu.sg/scorpion/.",

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AU - Brusic, Vladimir

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SCORPION2: a database for structure-function analysis of scorpion toxins

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