SCORPION2: a database for structure-function analysis of scorpion toxins

Paul T J Tan*, Anitha Veeramani, Kellathur N. Srinivasan, Shoba Ranganathan, Vladimir Brusic

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    42 Citations (Scopus)

    Abstract

    Scorpion toxins are important experimental tools for characterization of vast array of ion channels and serve as scaffolds for drug design. General public database entries contain limited annotation whereby rich structure-function information from mutation studies is typically not available. SCORPION2 contains more than 800 records of native and mutant toxin sequences enriched with binding affinity and toxicity information, 624 three-dimensional structures and some 500 references. SCORPION2 has a set of search and prediction tools that allow users to extract and perform specific queries: text searches of scorpion toxin records, sequence similarity search, extraction of sequences, visualization of scorpion toxin structures, analysis of toxic activity, and functional annotation of previously uncharacterized scorpion toxins. The SCORPION2 database is available at http://sdmc.i2r.a-star.edu.sg/scorpion/.

    Original languageEnglish
    Pages (from-to)356-363
    Number of pages8
    JournalToxicon
    Volume47
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2006

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