Screening for sleep apnoea in mild cognitive impairment

the utility of the multivariable apnoea prediction index

Georgina Wilson, Zoe Terpening, Keith Wong, Ron Grunstein, Louisa Norrie, Simon J. G. Lewis, Sharon L. Naismith

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Purpose. Mild cognitive impairment (MCI) is considered an "at risk" state for dementia and efforts are needed to target modifiable risk factors, of which Obstructive sleep apnoea (OSA) is one. This study aims to evaluate the predictive utility of the multivariate apnoea prediction index (MAPI), a patient self-report survey, to assess OSA in MCI. Methods. Thirty-seven participants with MCI and 37 age-matched controls completed the MAPI and underwent polysomnography (PSG). Correlations were used to compare the MAPI and PSG measures including oxygen desaturation index and apnoea-hypopnoea index (AHI). Receiver-operating characteristics (ROC) curve analyses were performed using various cut-off scores for apnoea severity. Results. In controls, there was a significant moderate correlation between higher MAPI scores and more severe apnoea (AHI: r = 0.47, P = 0.017). However, this relationship was not significant in the MCI sample. ROC curve analysis indicated much lower area under the curve (AUC) in the MCI sample compared to the controls across all AHI severity cut-off scores. Conclusions. In older people, the MAPI moderately correlates with AHI severity but only in those who are cognitively intact. Development of further screening tools is required in order to accurately screen for OSA in MCI.

Original languageEnglish
Article number945287
Pages (from-to)1-7
Number of pages7
JournalSleep disorders
Publication statusPublished - 2014
Externally publishedYes

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Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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    Wilson, G., Terpening, Z., Wong, K., Grunstein, R., Norrie, L., Lewis, S. J. G., & Naismith, S. L. (2014). Screening for sleep apnoea in mild cognitive impairment: the utility of the multivariable apnoea prediction index. Sleep disorders, 2014, 1-7. [945287].