Seed mediated one-pot growth of versatile heterogeneous upconversion nanocrystals for multimodal bioimaging

Shihui Wen, Du Li, Deming Liu, Xiaoxue Xu, Yi Du, David R G Mitchell, Bingyang Shi, Xiangyang Shi, Dayong Jin*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

1 Citation (Scopus)


The rapid development of a variety of molecular contrast agents makes the multimodality bioimaging highly attractive towards higher resolution, more sensitive, informative diagnosis. The key lies in the development of facile material synthesis that allows the integration of multiple contrast agents, ideally in a way that each of the components should be logically assembled to maximize their performances. Here, we report the one-pot programmable growth of multifunctional heterogeneous nanocrystal with tunable size, shape, composition, and properties. We demonstrated a facile one-pot hot-injection method to enable the highly selectively controlled growth of different sodium lanthanide fluoride nanomaterials in either longitudinal or transversal directions with atomic scale precision. This technique allows the upconversion luminescence signal, MRI signal and x-ray signal logically integrated and optimized within one single versatile nanoplatform for multimode bioimaging. These findings suggest that the facile strategy developed here have the promising to get the desired heterogeneous nanocrystals as an all-in-one contrast agent for integrated and self-correlative multimodal bioimaging.

Original languageEnglish
Title of host publicationSPIE BioPhotonics Australasia
EditorsMark R. Hutchinson, Ewa M. Goldys
Place of PublicationS.l.
Number of pages7
ISBN (Electronic)9781510604346
Publication statusPublished - 2016
EventSPIE BioPhotonics Australasia - Adelaide, Australia
Duration: 17 Oct 201619 Oct 2016


OtherSPIE BioPhotonics Australasia


  • heterogeneous growth
  • multimode imaging
  • one-pot synthesis
  • partitioned doping
  • Upconversion nanocrystals


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