Objective: This study determined whether CGG repeat length moderates the relationship between age and performance on selective measures of executive function in premutation carriers (PM) who are asymptomatic for a recently described late-onset neurodegenerative disorder, fragile X-associated tremor/ataxia syndrome (FXTAS). Methods: Forty PM men aged 18-69 years with a family history of fragile X syndrome underwent neuropsychological tests of inhibitionandworkingmemory.Weexaminedonlymenwhoareasymptomatic for FXTAS. Multiple regression analyses were conducted to examine the moderating role of CGG repeat length on the relation between age and performance on inhibition and working memory tasks. Results: With increasing age and only in men with an FMR1 expansion in the upper permutation range (>100 CGG repeats) was there an association between age and poorer task performance on selective executive function measures involving inhibition (p <0.05) and executive working memory (p <0.01). Men in the lower premutation range (<00 CGG repeats) were relatively risk-free from any cognitive aging effects associated with CGG repeat expansions. Conclusions: We conclude that neural networks in the prefrontal cortex may be highly susceptible to age-related neurotoxic effects in the upper size range of the FMR1 premutation. Future longitudinal studies will be needed to determine whether specific executive markers may serve to distinguish those at greatest risk for severe cognitive decline or dementia associated with FXTAS.