Self-reported physical activity is associated with tau burden measured by positron emission tomography

Belinda M. Brown*, Stephanie R. Rainey-Smith, Vincent Dore, Jeremiah J. Peiffer, Samantha C. Burnham, Simon M. Laws, Kevin Taddei, David Ames, Colin L. Masters, Christopher C. Rowe, Ralph N. Martins, Victor L. Villemagne

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)


    Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n=16) or high PA (HPA; n=27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22±1.98), compared to the HPA group (z-score: - 0.28±1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported PA level and brain tau burden. Future longitudinal and interventional studies utilizing larger samples sizes are vital to further investigate the nature of the relationship between tau and PA.

    Original languageEnglish
    Pages (from-to)1299-1305
    Number of pages7
    JournalJournal of Alzheimer's Disease
    Issue number4
    Publication statusPublished - 1 Jan 2018


    • Alzheimer's disease
    • physical activity
    • positron emission tomography
    • tau


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