Semantic memory is impaired in both dementia with Lewy bodies and dementia of Alzheimer's type

A comparative neuropsychological study and literature review

M. A. Lambon Ralph*, J. Powell, D. Howard, A. B. Whitworth, P. Garrard, J. R. Hodges

*Corresponding author for this work

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Objective - To test the hypothesis that semantic impairment is present in both patients with dementia with Lewy bodies (DLB) and those with dementia of Alzheimer's type (DAT). Methods - A comprehensive battery of neuropsychological tasks designed to assess semantic memory, visuoperceptual function, verbal fluency, and recognition memory was given to groups of patients with DLB (n=10), DAT (n=10) matched pairwise for age and mini mental state examination (MMSE), and age matched normal controls (n=15). Results - Both DLB and DAT groups exhibited impaired performance across the range of tasks designed to assess semantic memory. Whereas patients with DAT showed equivalent comprehension of written words and picture stimuli, patients with DLB demonstrated more severe semantic deficits for pictures than words. As in previous studies, patients with DLB but not those with DAT were found to have impaired visuoperceptual functioning. Letter and category fluency were equally reduced for the patients with DLB whereas performance on letter fluency was significantly better in the DAT group. Recognition memory for faces and words was impaired in both groups. Conclusions - Semantic impairment is not limited to patients with DAT. Patients with DLB exhibit particular problems when required to access meaning from pictures that is most likely to arise from a combination of semantic and visuoperceptual impairments.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume70
Issue number2
DOIs
Publication statusPublished - Feb 2001
Externally publishedYes

Keywords

  • Dementia of Alzheimer's type
  • Dementia with Lewy bodies
  • Neuropsychology
  • Semantic memory

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