Semiautomatic detection of villi in confocal endoscopy for the evaluation of celiac disease

D. Boschetto, H. Mirzaei, R. W L Leong, G. Tarroni, E. Grisan

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

5 Citations (Scopus)

Abstract

Celiac Disease (CD) is an immune-mediated enteropathy, diagnosed in the clinical practice by intestinal biopsy and the concomitant presence of a positive celiac serology. Confocal Laser Endomicroscopy (CLE) allows skilled and trained experts to potentially perform in vivo virtual histology of small-bowel mucosa. In particular, it allows the qualitative evaluation of mucosa alteration such as a decrease in goblet cells density, presence of villous atrophy or crypt hypertrophy. We present a semi-automatic method for villi detection from confocal endoscopy images, whose appearance change in case of villous atrophy. Starting from a set of manual seeds, a first rough segmentation of the villi is obtained by means of mathematical morphology operations. A merge and split procedure is then performed, to ensure that each seed originates a different region in the final segmentation. A border refinement process is finally performed, evolving the shape of each region according to local gradient intensities. Mean and median Dice coefficients for 290 villi originating from 66 images when compared to manually obtained ground truth are 80.71% and 87.96% respectively.

Original languageEnglish
Title of host publicationEMBC 2015
Subtitle of host publicationProceedings of the 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Place of PublicationNew York
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages8143-8146
Number of pages4
ISBN (Electronic)9781424492718, 9781424492701
DOIs
Publication statusPublished - 4 Nov 2015
Externally publishedYes
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: 25 Aug 201529 Aug 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period25/08/1529/08/15

Keywords

  • celiac disease
  • computer-aided diagnosis
  • confocal endomicroscopy
  • villous atrophy

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